Association of β-Amyloid, Microglial Activation, Cortical Thickness, and Metabolism in Older Adults Without Dementia

作者：Yue Cai, Dai Shi, Guoyu Lan, Linting Chen, Yanni Jiang, Liemin Zhou, Tengfei Guo, for the Alzheimer's Disease Neuroimaging Initiative · 发表于：Neurology · 年份：2024 · DOI：10.1212/wnl.0000000000209205 · 被引用次数：30 · 研究领域：Neuroinflammation and Neurodegeneration Mechanisms、Alzheimer's disease research and treatments、Dementia and Cognitive Impairment Research

Background and Objectives Plasma β-amyloid 42 (Aβ 42 )/Aβ 40 levels have shown promise in identifying Aβ-PET positive individuals. This study explored the concordance and discordance of plasma Aβ 42 /Aβ 40 positivity (Plasma±) with CSF Aβ 42 /Aβ 40 positivity (CSF±) and Aβ-PET positivity (PET±) in older adults without dementia. Associations of Aβ deposition, cortical thickness, glucose metabolism, and microglial activation were also investigated. Methods We selected participants without dementia who had concurrent plasma Aβ 42 /Aβ 40 and Aβ-PET scans from the Alzheimer's Disease Neuroimaging Initiative cohort. Participants were categorized into Plasma±/PET± based on thresholds of composite 18 F-florbetapir (FBP) standardized uptake value ratio (SUVR) ≥1.11 and plasma Aβ 42 /Aβ 40 ≤0.1218. Aβ-PET–negative individuals were further divided into Plasma±/CSF± (CSF Aβ 42 /Aβ 40 ≤0.138), and the concordance and discordance of Aβ 42 /Aβ 40 in the plasma and CSF were investigated. Baseline and slopes of regional FBP SUVR were compared among Plasma±/PET± groups, and associations of regional FBP SUVR, FDG SUVR, cortical thickness, and CSF soluble Triggering Receptor Expressed on Myeloid Cell 2 (sTREM2) levels were analyzed. Results One hundred eighty participants (mean age 72.7 years, 51.4% female, 96 cognitively unimpaired, and 84 with mild cognitive impairment) were included. We found that the proportion of Plasma+/PET− individuals was 6.14 times higher (odds ratio (OR) = 6.143, 95% c...