Comparative Efficacy and Safety of Radiofrequency Ablation and Microwave Ablation in the Treatment of Benign Thyroid Nodules: A Systematic Review and Meta-Analysis

作者：Hendra Zufry, Timotius Ivan Hariyanto · 发表于：Korean Journal of Radiology · 年份：2024 · DOI：10.3348/kjr.2023.1004 · 被引用次数：32 · 研究领域：Thyroid Cancer Diagnosis and Treatment、Thyroid and Parathyroid Surgery、Management of metastatic bone disease

Objective: The current body of evidence lacks clarity regarding the comparative efficacy and safety of radiofrequency ablation (RFA) and microwave ablation (MWA) as minimally invasive treatments for benign thyroid nodules.The primary objective of this study is to clarify these concerns. Materials and Methods:A comprehensive search was conducted using the Cochrane Library, Scopus, Europe PMC, and Medline databases until October 10th, 2023, using a combination of relevant keywords.This study incorporated literature that compared RFA and MWA for benign thyroid nodules.The primary outcome was the volume reduction ratio (VRR) from baseline to follow-up.Secondary outcomes were symptom score, cosmetic score, ablation time, major complications rate, hemorrhage, hoarseness, skin burn, cough, and sympathetic nerve injury.We used Risk of Bias in Non-randomized Studies -of Interventions (ROBINS-I) tool to assess the risk of bias in the included studies.We employed random effects models to analyze the standardized mean difference (SMD) and odds ratio for the presentation of outcomes.Results: Nine studies with 2707 nodules were included.The results of our meta-analysis indicated similar efficacy between RFA and MWA in terms of VRR during the 1 (SMD 0.06; 95% confidence interval [CI]: -0.13 to 0.26; P = 0.52) and 3 (SMD 0.11; 95% CI: -0.03 to 0.25; P = 0.12) months of follow-up.VRR was significantly higher in RFA than in MWA at the 6 (SMD 0.25; 95% CI: 0.06-0.43;P = 0.008) and 12 month of f...