Fibroblasts facilitate lymphatic vessel formation in transplanted heart

作者：Hui Gong, Ting Wang, Xiaotong Sun, Yuesheng Zhang, Yichao Qiu, Wenlong Sun, Yue Zhang, Peng Teng, Yanhua Hu, Xiaosheng Hu, Liang Ma, Qingbo Xu, Haige Zhao · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.92103 · 被引用次数：16 · 研究领域：Lymphatic System and Diseases、Congenital heart defects research、Mesenchymal stem cell research

Our study indicates that cardiac lymphangiogenesis primarily originates from recipient cells, and activated fibroblasts play a crucial role in facilitating the generation of lymphatic vessels after heart transplantation. These findings provide valuable insights into potential therapeutic targets for enhancing graft survival.