Tumor-derived extracellular vesicles as a biomarker for breast cancer diagnosis and metastasis monitoring

作者：Xu Feng, Ke Wang, Chengjun Zhu, Lingling Fan, Ye Zhu, Jacqueline Wang, Xintong Li, Yiqiu Liu, Yuhan Zhao, Chuandong Zhu, Wenwen Zhang, Fang Yang, Jian Xu, Zhe Li, Xiaoxiang Guan · 发表于：iScience · 年份：2024 · DOI：10.1016/j.isci.2024.109506 · 被引用次数：16 · 研究领域：Extracellular vesicles in disease、MicroRNA in disease regulation、Nanoplatforms for cancer theranostics

It is imperative to explore biomarkers that are both precise and readily accessible in the comprehensive management of breast cancer. A multicenter cohort, including 512 breast cancer patients and 198 nonneoplastic individuals, was recruited to detect the level of tumor-derived extracellular vesicles using our method based on dual DNA tetrahedral nanostructures. The level of tumor-derived extracellular vesicles was significantly higher in newly diagnosed breast cancer patients than in nonneoplastic individuals at a cutoff value of 3.58 U/μL. For postoperative metastasis monitoring, the level of tumor-derived extracellular vesicles was significantly higher in breast cancer patients with metastasis than in those without metastasis at a cutoff value of 3.91 U/μL. Its efficacy of diagnosis and metastasis monitoring was superior to traditional tumor markers. Elevated level of tumor-derived extracellular vesicles served as a predictive biomarker for diagnosis and metastasis monitoring in breast cancer patients.