A genome-wide cross-trait analysis identifies shared loci and causal relationships of obesity and lipidemic traits with psoriasis

作者：Wu Yuan, Mengfen Huang, Xueru Chen, Jingjing Wu, Li Li, Jianan Wei, Chuanjian Lu, Ling Han, Yue Lu · 发表于：Frontiers in Immunology · 年份：2024 · DOI：10.3389/fimmu.2024.1328297 · 被引用次数：10 · 研究领域：Psoriasis: Treatment and Pathogenesis、Retinoids in leukemia and cellular processes、Dermatology and Skin Diseases

Background Obesity and dyslipidemia, major global health concerns, have been linked to psoriasis, but previous studies faced methodological limitations and their shared genetic basis remains unclear. This study examines various obesity-related and lipidemic traits as potential contributors to psoriasis development, aiming to clarify their genetic associations and potential causal links. Methods Summary statistics from genome-wide association studies (GWAS) conducted for obesity-related traits (body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-hip ratio adjusted for the body mass index (WHR adj BMI)) and lipidemic traits (high-density lipoprotein (HDL), LDL, triglyceride (TG), total Cholesterol (TC), apolipoprotein A1 (apoA1), apolipoprotein B (apoB), and apolipoprotein E (apoE)) and psoriasis, all in populations of European ancestry, were used. We quantified genetic correlations, identified shared loci and explored causal relationship across traits. Results We found positive genetic correlation between BMI and psoriasis (r g =0.22, p=2.44×10 -18 ), and between WHR and psoriasis (r g =0.19, p=1.41×10 -12 ). We further found the positive genetic correlation between psoriasis and WHR adj BMI(r g =0.07, p=1.81×10 -2 ) the genetic correlation, in while the effect of BMI was controlled for. We identified 14 shared loci underlying psoriasis and obesity-related traits and 43 shared loci between psoriasis and lipidemic traits via cross-trait meta-analysis. Mendelian random...