Aza-Achmatowicz rearrangement coupled with intermolecular aza-Friedel–Crafts enables total syntheses of uleine and aspidosperma alkaloids

作者：Foqing Ma, Yunlong Li, Kornkamon Akkarasereenon, Huiying Qiu, Yuen Tsz Cheung, Zhihong Guo, Rongbiao Tong · 发表于：Chemical Science · 年份：2024 · DOI：10.1039/d4sc00601a · 被引用次数：6 · 研究领域：Alkaloids: synthesis and pharmacology、Asymmetric Synthesis and Catalysis、Chemical synthesis and alkaloids

An intermolecular aza-Friedel–Crafts reaction of indoles with aza-Achmatowicz rearrangement products is achieved efficiently with Brønsted acid and applied to collective total syntheses of three uleine-type and six aspidosperma alkaloids.