Effectiveness of a multidisciplinary and transitional nutritional intervention compared with standard care on health-related quality of life among acutely admitted medical patients aged ≥65 years with malnutrition or risk of malnutrition: A randomized controlled trial

作者：Aino Leegaard Andersen, Morten Baltzer Houlind, Rikke Lundsgaard Nielsen, Lillian Mørch Jørgensen, Anne Kathrine Bengaard, Olivia Bornæs, Helle Gybel Juul‐Larsen, Nikita Misella Hansen, Louise Dalsgaard Brøchner, Randi G. Hansen, Corneliah A.R. Skovlund, Anne Marie Lynge Pedersen, Anne Marie Beck, Mette Merete Pedersen, Janne Petersen, Ove Andersen · 发表于：Clinical Nutrition ESPEN · 年份：2024 · 被引用次数：11 · 研究领域：Nutrition and Health in Aging、Clinical Nutrition and Gastroenterology、Child Nutrition and Water Access

BACKGROUND & AIM: Malnutrition, risk of malnutrition, and risk factors for malnutrition are prevalent among acutely admitted medical patients aged ≥65 years and have significant health-related consequences. Consequently, we aimed to investigate the effectiveness of a multidisciplinary and transitional nutritional intervention on health-related quality of life compared with standard care. METHODS: The study was a block randomized, observer-blinded clinical trial with two parallel arms. The Intervention Group was offered a multidisciplinary transitional nutritional intervention consisting of dietary counselling and six sub-interventions targeting individually assessed risk factors for malnutrition, while the Control Group received standard care. The inclusion criteria were a Mini Nutritional Assessment Short-Form score ≤11, age ≥65 years, and an acute admittance to the Emergency Department. Outcomes were assessed on admission and 8 and 16 weeks after hospital discharge. The primary outcome was the difference between groups in change in health-related quality of life (assessed by the EuroQol-5D-5L) from baseline to 16 weeks after discharge. The secondary outcomes were difference in intake of energy and protein, well-being, muscle strength, and body weight at all timepoints. RESULTS: From October 2018 to April 2021, 130 participants were included. Sixteen weeks after discharge, 29% in the Intervention Group and 19% in the Control Group were lost to follow-up. Compliance varied be...