Multicomponent Intervention for Overactive Bladder in Women

作者：Satoshi Funada, Yan Luo, Ryuji Uozumi, Norio Watanabe, Takayuki Goto, Hiromitsu Negoro, Kentaro Ueno, Kentaro Ichioka, Takehiko Segawa, Tatsuo Akechi, Osamu Ogawa, Shusuke Akamatsu, Takashi Kobayashi, Toshi A. Furukawa · 发表于：JAMA Network Open · 年份：2024 · DOI：10.1001/jamanetworkopen.2024.1784 · 被引用次数：17 · 研究领域：Urinary Bladder and Prostate Research、Pelvic floor disorders treatments、Urinary Tract Infections Management

Importance: Although the cognitive components of behavioral therapy for overactive bladder (OAB) are widely recognized, there is a lack of studies evaluating the effectiveness of multicomponent interventions that include cognitive components as a treatment for OAB. Objective: To examine the efficacy of a multicomponent intervention in improving health-related quality of life (HRQOL) for women with moderate to severe OAB. Design, Setting, and Participants: This multicenter, open-label, randomized clinical trial was conducted in Japan among women aged 20 to 80 years who had moderate to severe OAB. Participants were recruited from 4 institutions between January 16, 2020, and December 31, 2022, through self-referral via advertisement or referral from the participating institutions. Interventions: Participants were randomized 1:1 by minimization algorithm using an internet-based central cloud system to four 30-minute weekly sessions of a multicomponent intervention or waiting list. Both groups continued to receive baseline treatment throughout the study period. Main Outcomes and Measures: The primary outcome was the least-squares mean changes from baseline through week 13 in HRQOL total scores of the OAB questionnaire between 2 groups. Secondary outcomes included OAB symptom score and frequency volume chart. Results: A total of 79 women were randomized to either the intervention group (39 participants; mean [SD] age, 63.5 [14.6] years) or the waiting list control group (40 partici...