Clinical efficacy of probiotics in the treatment of alcoholic liver disease: a systematic review and meta-analysis

作者：Shi-Ying Xiong, Gui-Sheng Wu, Chun Li, Wenzhe Ma, Huai‐Rong Luo · 发表于：Frontiers in Cellular and Infection Microbiology · 年份：2024 · DOI：10.3389/fcimb.2024.1358063 · 被引用次数：30 · 研究领域：Alcohol Consumption and Health Effects、Liver Disease Diagnosis and Treatment、Liver Disease and Transplantation

Objective Alcoholic liver disease (ALD) is a liver damage disease caused by long-term heavy drinking. Currently, there is no targeted pharmaceutical intervention available for the treatment of this disease. To address this, this paper evaluates the efficacy and safety of probiotic preparation in treating ALD through conducting a meta-analysis, and provides a valuable insight for clinical decision-making. Methods A systematic search was conducted across databases, including PubMed, Embase, Web of Science, Cochrane Library, CNKI, VIP, Wanfang, and CBM from the inception dates to October 15, 2023, to identify clinical randomized controlled trials on probiotic preparations in the treatment of ALD. After the literature underwent screening, data extraction, and quality assessment, RevMan 5.3 and Stata 14.2 were employed for data analysis and processing. Results A total of 9 randomized controlled trials fulfilled the inclusion criteria. The results of the meta-analysis showed that probiotic preparation could significantly improve the liver function of patients with alcoholic liver disease compared with the control group. Probiotic intervention led to a significant reduction in the levels of alanine aminotransferase (MD=-13.36,95%CI:-15.80,-10.91; P <0.00001),aspartate aminotransferase (MD=-16.99,95%CI:-20.38,-13.59; P <0.00001),γ-glutamyl transpeptidase (MD=-18.79,95% CI:-28.23,-9.34; P <0.0001). Concurrently, the level of serum albumin (MD=0.19,95% CI:0.02,0.36; P =0.03) was increa...