Recommendations on maximising the clinical value of tissue in the management of patients with intrahepatic cholangiocarcinoma

作者：Timothy J. Kendall, Diletta Overi, Maria Guido, Chiara Braconi, Jesús M. Bañales, Vincenzo Cardinale, Eugenio Gaudio, Bas Groot Koerkamp, Guido Carpino · 发表于：JHEP Reports · 年份：2024 · DOI：10.1016/j.jhepr.2024.101067 · 被引用次数：7 · 研究领域：Cholangiocarcinoma and Gallbladder Cancer Studies、Gastric Cancer Management and Outcomes、Pancreatic and Hepatic Oncology Research

Background & Aims: Patients with intrahepatic cholangiocarcinoma can now be managed with targeted therapies directed against specific molecular alterations. Consequently, tissue samples submitted to the pathology department must produce molecular information in addition to a diagnosis or, for resection specimens, staging information. The pathologist's role when evaluating these specimens has therefore changed to accommodate such personalised approaches. Methods: We developed recommendations and guidance for pathologists by conducting a systematic review of existing guidance to generate candidate statements followed by an international Delphi process. Fifty-nine pathologists from 28 countries in six continents rated statements mapped to all elements of the specimen pathway from receipt in the pathology department to authorisation of the final written report. A separate survey of 'end-users' of the report including surgeons, oncologists, and gastroenterologists was undertaken to evaluate what information should be included in the written report to enable appropriate patient management. Results: Forty-eight statements reached consensus for inclusion in the guidance including 10 statements about the content of the written report that also reached consensus by end-user participants. A reporting proforma to allow easy inclusion of the recommended data points was developed. Conclusions: These guiding principles and recommendations provide a framework to allow pathologists reporting ...