The interaction of lipocalin-2 and astrocytes in neuroinflammation: mechanisms and therapeutic application

作者：Qianqian Tan, Chenxi Zhang, Xiuqin Rao, Wei Wan, Wei Lin, Shupeng Huang, Jun Ying, Yue Lin, Fuzhou Hua · 发表于：Frontiers in Immunology · 年份：2024 · DOI：10.3389/fimmu.2024.1358719 · 被引用次数：38 · 研究领域：Neuroinflammation and Neurodegeneration Mechanisms、Anesthesia and Neurotoxicity Research、Traumatic Brain Injury and Neurovascular Disturbances

Neuroinflammation is a common pathological process in various neurological disorders, including stroke, Alzheimer's disease, Parkinson's disease, and others. It involves the activation of glial cells, particularly astrocytes, and the release of inflammatory mediators. Lipocalin-2 (Lcn-2) is a secretory protein mainly secreted by activated astrocytes, which can affect neuroinflammation through various pathways. It can also act as a pro-inflammatory factor by modulating astrocyte activation and polarization through different signaling pathways, such as NF-κB, and JAK-STAT, amplifying the inflammatory response and aggravating neural injury. Consequently, Lcn-2 and astrocytes may be potential therapeutic targets for neuroinflammation and related diseases. This review summarizes the current knowledge on the role mechanisms, interactions, and therapeutic implications of Lcn-2 and astrocytes in neuroinflammation.