Diagnostic accuracy of oral swab for detection of pulmonary tuberculosis: a systematic review and meta-analysis

作者：Fuzhen Zhang, Yilin Wang, Xuxia Zhang, Kewei Liu, Yuanyuan Shang, Wei Wang, Yuan-Yuan Liu, L. Li, Yu Pang · 发表于：Frontiers in Medicine · 年份：2024 · DOI：10.3389/fmed.2023.1278716 · 被引用次数：21 · 研究领域：Oral microbiology and periodontitis research、HIV/AIDS oral health manifestations、Oral Health Pathology and Treatment

Objectives: (MTB) within oral epithelial cells. Due to disparities in the diagnostic performance of OSA reported in the original studies, we conducted a meticulous meta-analysis to comprehensively assess the diagnostic efficacy of OSA in pulmonary TB. Methods: We conducted a comprehensive investigation across multiple databases, namely PubMed, Cochrane Library, Embase, Web of Science, ClinicalTrials.gov, Chinese BioMedical Literature Database (CBM), China National Knowledge Infrastructure Database (CNKI), and Wanfang China Science and Technology Journal Database to identify relevant studies. Out search query utilized the following keywords: oral swab, buccal swab, tongue swab, tuberculosis, and TB. Subsequently, we employed STATA 16.0 to compute the combined sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio for both the overall and subgroup analyses. Results: Our findings indicated that OSA has a combined sensitivity of 0.67 and specificity of 0.95 in individuals with pulmonary TB. Subgroup analysis further revealed that among adult individuals with pulmonary TB, the sensitivity and specificity of OSA were 0.73 and 0.93, respectively. In HIV-negative individuals with pulmonary TB, the sensitivity and specificity were 0.68 and 0.98, respectively. The performance of OSA in detecting pulmonary TB correlated with the bacteria load in sputum. Additionally, the sensitivity for diagnosing pulmonary TB using tongue specimens was...