Surface charge-induced electrospray for high-throughput analysis of complex samples and electrochemical reaction intermediates using mass spectrometry

作者：Yajie Huang, Yajun Zheng, Qianqian Zuo, Zhiming Zhang, Zhiming Zhang, Lixuan Zhu, Yun Li, Zhiping Zhang, Zhiping Zhang · 发表于：Analytical Methods · 年份：2024 · DOI：10.1039/d4ay00276h · 被引用次数：1 · 研究领域：Mass Spectrometry Techniques and Applications、Ion-surface interactions and analysis、Analytical Chemistry and Chromatography

Electrospray-related ion sources are promising for direct mass spectrometric analysis of complex samples, but current protocols suffer from complicated components and low analytical sensitivity. Here, we propose a surface charge-induced electrospray ionization (SCIESI) inspired by flashover on an insulator surface under high voltage. This protocol not only effectively avoids contact between the sample solution and metal electrode, but also allows completion of the entire analytical process in less than 40 seconds and limits of detection in the pictogram per milliliter range. SCIESI coupled to mass spectrometry can also be used to monitor electro-chemical processes, and a number of oxidation and reduction reactions have been studied, demonstrating that it is a powerful tool for understanding electrochemical reaction mechanisms.