Photodriven Radical Perfluoroalkylation–Thiolation of Unactivated Alkenes Enabled by Electron Donor–Acceptor Complex

作者：Lixin Liu, Qian Wang, Yuanhua Li, Min Liu, Bifu Liu, Qiang Li, Kejun Feng · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c00462 · 被引用次数：27 · 研究领域：Fluorine in Organic Chemistry、Sulfur-Based Synthesis Techniques、Radical Photochemical Reactions

A clean and direct three-component radical 1,2-difunctionalization of various alkenes with perfluoroalkyl iodides and thiosulfonates enabled by the electron donor–acceptor complex has been developed under light illumination at room temperature. The approach offers a convenient and environmentally friendly route for the simultaneous incorporation of Csp 3 –R f and Csp 3 –S bonds, affording valuable polyfunctionalized alkane derivatives containing fluorine and sulfur in satisfactory yields. Consequently, this methodology holds significant value and practicality in the field of organic synthesis.