Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health

作者：Ifene David Festus, Jeri Spilberg, Martin Elliot Young, Sean W. Cain, Sepideh Khoshnevis, Michael H. Smolensky, Fariya Zaheer, Giannina Descalzi, Tami A. Martino · 发表于：Trends in Endocrinology and Metabolism · 年份：2024 · DOI：10.1016/j.tem.2024.02.011 · 被引用次数：32 · 研究领域：Circadian rhythm and melatonin、Dietary Effects on Health、Climate Change and Health Impacts

Cardiovascular disease (CVD) is a global health concern. Circadian medicine improves cardiovascular care by aligning treatments with our body's daily rhythms and their underlying cellular circadian mechanisms. Time-based therapies, or chronotherapies, show special promise in clinical cardiology. They optimize treatment schedules for better outcomes with fewer side effects by recognizing the profound influence of rhythmic body cycles. In this review, we focus on three chronotherapy areas (medication, light, and meal timing) with potential to enhance cardiovascular care. We also highlight pioneering research in the new field of rest, the gut microbiome, novel chronotherapies for hypertension, pain management, and small molecules that targeting the circadian mechanism.