The development and initial validation of IgG4-related disease damage index: a consensus report from Chinese IgG4-RD Consortium

作者：Linyi Peng, Jingna Li, Jiaxin Zhou, Yunyun Fei, Lingli Dong, Yanying Liu, Dingding Zhang, Yanhong Wang, Shuhong Chi, Fang Wang, Yunxia Hou, Xiaoping Hong, Hongsheng Sun, Yujin Ye, Nan Che, Rong Zhang, Changyan Liu, Zongfei Ji, Wenjia Sun, Cheng Zhao, Ning Ma, Yamin Lai, Mengtao Li, Yan Zhao, Xiaofeng Zeng, Liwei Lu, Wen Zhang · 发表于：RMD Open · 年份：2024 · DOI：10.1136/rmdopen-2023-003938 · 被引用次数：8 · 研究领域：IgG4-Related and Inflammatory Diseases、Sinusitis and nasal conditions、Clinical Reasoning and Diagnostic Skills

OBJECTIVE: To develop and conduct an initial validation of the Damage Index for IgG4-related disease (IgG4-RD DI). METHODS: A draft of index items for assessing organ damages in patients with IgG4-RD was generated by experts from the Chinese IgG4-RD Consortium (CIC). The preliminary DI was refined using the Delphi method, and a final version was generated by consensus. 40 IgG4-RD cases representing four types of clinical scenarios were then selected, each with two time points of assessment for at least 3 years of follow-up. 48 rheumatologists from 35 hospitals nationwide were invited to evaluate organ damage using the CIC IgG4-RD DI. The intraclass correlation coefficient (ICC) and the Kendall-W coefficient of concordance (KW) were used to assess the inter-rater reliability. The criterion validity of IgG4-RD DI was tested by calculating the sensitivity and specificity of raters. RESULTS: IgG4-RD DI is a cumulative index consisting of 14 domains of organ systems, including a total of 39 items. The IgG4-RD DI was capable of distinguishing stable and increased damage across the active disease subgroup and stable disease subgroup. In terms of scores at baseline and later observations by all raters, overall consistency in scores at baseline and later observations by all raters was satisfactory. ICC at the two time points was 0.69 and 0.70, and the KW was 0.74 and 0.73, respectively. In subgroup analysis, ICC and KW in all subgroups were over 0.55 and 0.61, respectively. The analys...