Nanoparticles traversing the extracellular matrix induce biophysical perturbation of fibronectin depicted by surface chemistry

作者：Xing Guo, Lin Yang, Chaofan Deng, Luyao Ren, Shixin Li, Xianren Zhang, Jian Zhao, Tongtao Yue · 发表于：Nanoscale · 年份：2024 · DOI：10.1039/d3nr06305d · 被引用次数：6 · 研究领域：Cell Adhesion Molecules Research、Nanoparticle-Based Drug Delivery、Nanoplatforms for cancer theranostics

selectively occupy the RGD/PHSRN motifs, which may hinder their recognition by integrins on the cell surface. Additionally, NPs can disrupt the dimerization of Fn through competing for residues at the dimer interface or by diminishing the shape complementarity between dimerized proteins. The mechanical stretching of Fn, crucial for ECM fibrillogenesis, is suppressed by NPs due to their local rigidifying effect. These results provide valuable molecular-level insights into the impacts of various NPs on the ECM, holding significant implications for advancing nanomedicine and nanosafety evaluation.