Synthesis of Benzo[e][1,3]thiazin‐4‐ones via PPh3‐Promoted Cyclization of Benzo[c][1,2]dithiol‐3‐ones and Amidines

作者：Xiaobing Liu, Wen‐Xin Lv, Junjie Dong, Zekai Liu, Feng Hu, Chuncheng Zhou, Yao Zhou · 发表于：Advanced Synthesis & Catalysis · 年份：2024 · DOI：10.1002/adsc.202301504 · 被引用次数：16 · 研究领域：Sulfur-Based Synthesis Techniques、Phenothiazines and Benzothiazines Synthesis and Activities、Synthesis of heterocyclic compounds

Abstract A phosphine‐mediated cyclization of benzo[c][1,2]dithiol‐3‐ones and amidines is demonstrated herein. Triphenylphosphine was harnessed as the activating reagent to facilitate the ring‐opening of benzo[c][1,2]dithiol‐3‐ones via S−S bond cleavage. This PPh 3 ‐Promoted cyclization reaction of benzo[c][1,2]dithiol‐3‐ones enabled to forge a diverse array of 1,3‐benzothiazones in decent yields with wide substrate scope under mild conditions.