MOG Antibodies Restricted to CSF in Children With Inflammatory CNS Disorders

作者：Gemma Olivé-Cirera, Arlette L. Bruijstens, Elianet Fonseca, Li‐Wen Chen, Eva Caballero, Eugenia Martínez‐Hernández, Mar Guasp, María Sepúlveda, Laura Naranjo, Raquel Ruiz‐García, Yolanda Blanco, Albert Saiz, Josep Dalmau, Thaís Armangué, for the Spanish Pediatric MOGAD Study Group · 发表于：Neurology · 年份：2024 · DOI：10.1212/wnl.0000000000209199 · 被引用次数：16 · 研究领域：Multiple Sclerosis Research Studies、Autoimmune Neurological Disorders and Treatments、Long-Term Effects of COVID-19

ObjectivesTo assess the clinical significance of myelin oligodendrocyte glycoprotein antibodies (MOG-abs) restricted to CSF in children with inflammatory CNS disorders. MethodsPatients included 760 children (younger than 18 years) from 3 multicenter prospective cohort studies: (A) acquired demyelinating syndromes, including acute disseminated encephalomyelitis (ADEM); (B) non-ADEM encephalitis; and (C) noninflammatory neurologic disorders. For all cases, paired serum/CSF samples were systematically examined using brain immunohistochemistry and live cell-based assays. ResultsA total of 109 patients (14%) had MOG-abs in serum or CSF: 79 from cohort A, 30 from B, and none from C. Of these, 63 (58%) had antibodies in both samples, 37 (34%) only in serum, and 9 (8%) only in CSF. Children with MOG-abs only in CSF were older than those with MOG-abs only in serum or in both samples (median 12 vs 6 vs 5 years, p = 0.0002) and were more likely to have CSF oligoclonal bands (86% vs 12% vs 7%, p = 0.0001) and be diagnosed with multiple sclerosis (6/9 [67%] vs 0/37 [0%] vs 1/63 [2%], p < 0.0001). DiscussionDetection of MOG-abs in serum or CSF is associated with CNS inflammatory disorders. Children with MOG-abs restricted to CSF are more likely to have CSF oligoclonal bands and multiple sclerosis than those with MOG-abs detectable in serum.