Self-Metallized Whole Cell Vaccines Prepared by Microfluidics for Bioorthogonally Catalyzed Antitumor Immunotherapy

作者：Fei Zeng, Yongchun Pan, Mengnan Wu, Qianglan Lu, Shurong Qin, Yanfeng Gao, Xiaowei Luan, Ruiyue Chen, Guanzhong He, Yuzhen Wang, Bangshun He, Zhaowei Chen, Yujun Song · 发表于：ACS Nano · 年份：2024 · DOI：10.1021/acsnano.3c09871 · 被引用次数：23 · 研究领域：Innovative Microfluidic and Catalytic Techniques Innovation、Monoclonal and Polyclonal Antibodies Research、Immunotherapy and Immune Responses

Tumor whole cell, carrying a complete set of tumor-associated antigens and tumor-specific antigens, has shown great potential in the construction of tumor vaccines but is hindered by the complex engineering means and limited efficacy to cause immunity. Herein, we provided a strategy for the self-mineralization of autologous tumor cells with palladium ions in microfluidic droplets, which endowed the engineered cells with both immune and catalytic functions, to establish a bioorthogonally catalytic tumor whole-cell vaccine. This vaccine showed strong inhibition both in the occurrence and recurrence of tumor by invoking the immediate antitumor immunity and building a long-term immunity.