The potential role of hydrogen sulfide in cancer cell apoptosis

作者：Wei Gao, Yafang Liu, Yanxia Zhang, Yan Wang, Yuqing Jin, Hang Yuan, Xiaoyi Liang, Xin‐Ying Ji, Qiying Jiang, Dongdong Wu · 发表于：Cell Death Discovery · 年份：2024 · DOI：10.1038/s41420-024-01868-w · 被引用次数：75 · 研究领域：Sulfur Compounds in Biology、Fibroblast Growth Factor Research、Polyamine Metabolism and Applications

Abstract For a long time, hydrogen sulfide (H 2 S) has been considered a toxic compound, but recent studies have found that H 2 S is the third gaseous signaling molecule which plays a vital role in physiological and pathological conditions. Currently, a large number of studies have shown that H 2 S mediates apoptosis through multiple signaling pathways to participate in cancer occurrence and development, for example, PI3K/Akt/mTOR and MAPK signaling pathways. Therefore, the regulation of the production and metabolism of H 2 S to mediate the apoptotic process of cancer cells may improve the effectiveness of cancer treatment. In this review, the role and mechanism of H 2 S in cancer cell apoptosis in mammals are summarized.