IgA-mediated control of host-microbial interaction during weaning reaction influences gut inflammation

作者：Wenjie Tang, Yusen Wei, Zhixiang Ni, Kangwei Hou, Xin Luo, Haifeng Wang · 发表于：Gut Microbes · 年份：2024 · DOI：10.1080/19490976.2024.2323220 · 被引用次数：16 · 研究领域：Gut microbiota and health、T-cell and B-cell Immunology、Clostridium difficile and Clostridium perfringens research

The mechanisms of how host-microbe mutualistic relationships are established at weaning contingently upon B-cell surveillance remain inadequately elucidated. We found that CD138+ plasmacyte (PC)-mediated promotion of IgA response regulates the symbiosis between Bacteroides uniformis (B. uniformis) and the host during the weaning period. The IgA-skewed response of CD138+ PCs is essential for B. uniformis to occupy a defined gut luminal niche, thereby fostering stable colonization. Furthermore, B. uniformis within the natural gut niche was perturbed in the absence of IgA, resulting in exacerbated gut inflammation in IgA-deficient mice and weaned piglets. Thus, we propose that the priming and maintenance of intestinal IgA response from CD138+ PCs are required for host-microbial symbiosis, whereas the perturbation of which would enhance inflammation in weaning process.