Clinical feasibility study of early 30-minute dynamic FDG-PET scanning protocol for patients with lung lesions

作者：Fen Du, Xieraili Wumener, Yarong Zhang, Maoqun Zhang, Jiuhui Zhao, Jinpeng Zhou, Yiluo Li, Bin Huang, Rongliang Wu, Zeheng Xia, Zhiheng Yao, Tao Sun, Ying Liang · 发表于：EJNMMI Physics · 年份：2024 · DOI：10.1186/s40658-024-00625-3 · 被引用次数：11 · 研究领域：Lung Cancer Diagnosis and Treatment、Medical Imaging Techniques and Applications、Radiomics and Machine Learning in Medical Imaging

PURPOSE: F-FDG) positron emission tomography (PET) scanning protocol for patients with lung lesions in comparison to the standard 65-minute dynamic FDG-PET scanning as a reference. METHODS: F-FDG PET images of 146 patients with 181 lung lesions (including 146 lesions confirmed by histology) were analyzed in this prospective study. Dynamic images were reconstructed into 28 frames with a specific temporal division protocol for the scan data acquired 65 min post-injection. Ki images and quantitative parameters Ki based on two different acquisition durations [the first 30 min (Ki-30 min) and 65 min (Ki-65 min)] were obtained by applying the irreversible two-tissue compartment model using in-house Matlab software. The two acquisition durations were compared for Ki image quality (including visual score analysis and number of lesions detected) and Ki value (including accuracy of Ki, the value of differential diagnosis of lung lesions and prediction of PD-L1 status) by Wilcoxon's rank sum test, Spearman's rank correlation analysis, receiver operating characteristic (ROC) curve, and the DeLong test. The significant testing level (alpha) was set to 0.05. RESULTS: The quality of the Ki-30 min images was not significantly different from the Ki-65 min images based on visual score analysis (P > 0.05). In terms of Ki value, among 181 lesions, Ki-65 min was statistically higher than Ki-30 min (0.027 ± 0.017 ml/g/min vs. 0.026 ± 0.018 ml/g/min, P < 0.05), while a very high correlation was obt...