Quantitative and Qualitative Parameters of DCE-MRI Predict CDKN2A/B Homozygous Deletion in Gliomas

作者：Huiquan Yang, Zhengyang Zhu, Cong Long, Fengnan Niu, Jianan Zhou, Sixuan Chen, Meiping Ye, Siqi Peng, Xue Zhang, Xue Zhang, Ying Chen, Liangpeng Wei, Haoyao Wang, Dongming Liu, Mei Yao, Xin Zhang, Xin Zhang, Bing Zhang · 发表于：Academic Radiology · 年份：2024 · DOI：10.1016/j.acra.2024.02.017 · 被引用次数：8 · 研究领域：Glioma Diagnosis and Treatment、Radiomics and Machine Learning in Medical Imaging、Brain Tumor Detection and Classification

Rationale and Objectives Homozygous deletion (HD) of CDKN2A/B holds important prognostic value in gliomas. This study aimed to explore the predictive potential of conventional MRI characteristics combined with dynamic contrast-enhanced MRI parameters in predicting CDKN2A/B HD status in gliomas. Materials and Methods Preoperative MRI data of 105 patients (69 without CDKN2A/B HD, and 36 with CDKN2A/B homozygous deletion) with gliomas were retrospectively collected. Conventional MRI features and dynamic contrast-enhanced-MRI qualitative parameter time-intensity curve type, quantitative parameters K trans , K ep , V e , V p , and iAUC were obtained. Logistic regression models for prediction of CDKN2A/B HD status were constructed in all types of gliomas and both subtypes of IDH-mutant and IDH-wild gliomas. Results Multivariate analysis for all patients demonstrated that age (OR=1.103, p = 0.002) and K trans (OR=1.051, p < 0.001) independently predicted CDKN2A/B HD. In IDH-mutant subgroup, multivariate analysis results indicated that K trans (OR=1.098, p = 0.031) emerged as autonomous predictors of CDKN2A/B HD. In IDH-wild subgroup, age (OR=1.111, p = 0.002) and K trans (OR=1.032, p = 0.001) were independent predictors of CDKN2A/B HD according to the multivariate analysis. The areas under the receiver operating characteristic curve of the corresponding models were 0.90, 0.95 and 0.84, respectively. Conclusion K trans can serve as valuable predictive parameters for identifying CDKN2...