A potential brain functional biomarker distinguishing patients with Crohn’s disease with different disease stages: a resting-state fMRI study

作者：Mengting Huang, Guina Ma, Yan Zou, Hui Ma, Wenliang Fan, Xin Li, Liangru Zhu, Ping Han, Huan Wang, Heshui Shi · 发表于：Frontiers in Neuroscience · 年份：2024 · DOI：10.3389/fnins.2024.1361320 · 被引用次数：12 · 研究领域：Functional Brain Connectivity Studies、Inflammatory Bowel Disease、Gastrointestinal motility and disorders

Background The previous studies have demonstrated that patients with Crohn’s disease in remission (CD-R) have abnormal alterations in brain function. However, whether brain function changes in patients with Crohn’s disease in activity (CD-A) and the relationship with CD-R are still unclear. In this study, we aimed to investigate whether the different levels of disease activity may differentially affect the brain function and to find the brain functional biomarker distinguishing patients with different disease stages by measuring the amplitude of low frequency fluctuations (ALFF). Methods 121 patients with CD and 91 healthy controls (HCs) were recruited. The clinical and psychological assessment of participants were collected. The criteria for the disease activity were the Crohn’s disease activity index (CDAI) scores. CD-R refers to CD patients in remission which the CDAI score is less than 150. Conversely, CD-A refers to CD patients in activity which the CDAI score is ≥150. The ALFF was compared among three groups by performing one-way analysis of variance, followed by a post hoc two-sample t-test. Differences among the groups were selected as seeds for functional connectivity analyses. We also investigated the correlation among clinical, psychological scores and ALFF. Binary logistic regression analysis was used to examine the unique contribution of the ALFF characteristics of the disease stages. Results There were widespread differences of ALFF values among the 3 groups, wh...