IGF1 promotes human myotube differentiation toward a mature metabolic and contractile phenotype

作者：Simon I. Dreher, Paul Grubba, Christine von Toerne, Alessia Moruzzi, Jennifer Maurer, Thomas Goj, Andreas L. Birkenfeld, Andreas Peter, Peter Loskill, Stefanie M. Hauck, Cora Weigert · 发表于：American Journal of Physiology-Cell Physiology · 年份：2024 · DOI：10.1152/ajpcell.00654.2023 · 被引用次数：19 · 研究领域：Muscle Physiology and Disorders、Cardiomyopathy and Myosin Studies、Genetic Neurodegenerative Diseases

Human skeletal muscle models are highly valuable to study how exercise prevents type 2 diabetes without invasive biopsies. Current models did not fully recapitulate the function of skeletal muscle especially during exercise. By supplementing insulin-like growth factor 1 (IGF1), the authors developed a functional human skeletal muscle model characterized by inducible contractility and increased oxidative and insulin-sensitive metabolism. The novel protocol overcomes the limitations of previous standards and enables investigation of exercise on a molecular level.