PRMT5 Promotes T follicular helper Cell Differentiation and Germinal Center Responses during Influenza Virus Infection

作者：Kaitlin A. Read, Stephanie A. Amici, Sadaf Farsi, Madeline P. Cutcliffe, Bella Lee, Chan‐Wang Jerry Lio, H. Wu, Mireia Guerau‐de‐Arellano, Kenneth J. Oestreich · 发表于：The Journal of Immunology · 年份：2024 · DOI：10.4049/jimmunol.2300270 · 被引用次数：3 · 研究领域：Cancer-related gene regulation、Immune Cell Function and Interaction

Protein arginine methyltransferases (PRMTs) modify diverse protein targets and regulate numerous cellular processes; yet, their contributions to individual effector T cell responses during infections are incompletely understood. In this study, we identify PRMT5 as a critical regulator of CD4+ T follicular helper cell (Tfh) responses during influenza virus infection in mice. Conditional PRMT5 deletion in murine T cells results in an almost complete ablation of both Tfh and T follicular regulatory populations and, consequently, reduced B cell activation and influenza-specific Ab production. Supporting a potential mechanism, we observe elevated surface expression of IL-2Rα on non-T regulatory effector PRMT5-deficient T cells. Notably, IL-2 signaling is known to negatively impact Tfh differentiation. Collectively, our findings identify PRMT5 as a prominent regulator of Tfh programming, with potential causal links to IL-2 signaling.