Decoding the potential role of regulatory T cells in sepsis‐induced immunosuppression

作者：Siyuan Huang, Di Liu, Lei Han, Jin Deng, Zhen Wang, Jianxin Jiang, Ling Zeng · 发表于：European Journal of Immunology · 年份：2024 · DOI：10.1002/eji.202350730 · 被引用次数：23 · 研究领域：Immune Cell Function and Interaction、T-cell and B-cell Immunology、Immune Response and Inflammation

Sepsis, a multiorgan dysfunction with high incidence and mortality, is caused by an imbalanced host-to-infection immune response. Organ-support therapy improves the early survival rate of sepsis patients. In the long term, those who survive the "cytokine storm" and its secondary damage usually show higher susceptibility to secondary infections and sepsis-induced immunosuppression, in which regulatory T cells (Tregs) are evidenced to play an essential role. However, the potential role and mechanism of Tregs in sepsis-induced immunosuppression remains elusive. In this review, we elucidate the role of different functional subpopulations of Tregs during sepsis and then review the mechanism of sepsis-induced immunosuppression from the aspects of regulatory characteristics, epigenetic modification, and immunometabolism of Tregs. Thoroughly understanding how Tregs impact the immune system during sepsis may shed light on preclinical research and help improve the translational value of sepsis immunotherapy.