CAR-NK cells in combination therapy against cancer: A potential paradigm

作者：Junping Li, Hong‐Ming Hu, Kai Lian, Dongdong Zhang, Pengchao Hu, Zhibing He, Zhenfeng Zhang, Yong Wang · 发表于：Heliyon · 年份：2024 · DOI：10.1016/j.heliyon.2024.e27196 · 被引用次数：34 · 研究领域：Immune Cell Function and Interaction、CAR-T cell therapy research、Cancer Immunotherapy and Biomarkers

Various preclinical and a limited number of clinical studies of CAR-NK cells have shown promising results: efficient elimination of target cells without side effects similar to CAR-T therapy. However, the homing and infiltration abilities of CAR-NK cells are poor due to the inhibitory tumor microenvironment. From the perspective of clinical treatment strategies, combined with the biological and tumor microenvironment characteristics of NK cells, CAR-NK combination therapy strategies with anti-PD-1/PD-L1, radiotherapy and chemotherapy, kinase inhibitors, proteasome inhibitors, STING agonist, oncolytic virus, photothermal therapy, can greatly promote the proliferation, migration and cytotoxicity of the NK cells. In this review, we will summarize the targets selection, structure constructions and combinational therapies of CAR-NK cells for tumors to provide feasible combination strategies for overcoming the inhibitory tumor microenvironment and improving the efficacy of CAR-NK cells.