Changes in bile acid subtypes and improvements in lipid metabolism and atherosclerotic cardiovascular disease risk: the Preventing Overweight Using Novel Dietary Strategies (POUNDS Lost) trial

作者：Yoriko Heianza, Qiaochu Xue, Jennifer Rood, Clary B. Clish, George A. Bray, Frank M. Sacks, Lu Qi · 发表于：American Journal of Clinical Nutrition · 年份：2024 · DOI：10.1016/j.ajcnut.2024.02.019 · 被引用次数：11 · 研究领域：Drug Transport and Resistance Mechanisms、Gut microbiota and health、Liver Disease Diagnosis and Treatment

Distinct circulating bile acid (BA) subtypes may play roles in regulating lipid homeostasis and atherosclerosis. We investigated whether changes in circulating BA subtypes induced by weight-loss dietary interventions were associated with improved lipid profiles and atherosclerotic cardiovascular disease (ASCVD) risk estimates. This study included adults with overweight or obesity (n=536) who participated in a randomized weight-loss diet intervention trial. Circulating primary and secondary unconjugated BAs and their taurine-/glycine-conjugates were measured at baseline and 6 months after weight-loss diet interventions. The ASCVD risk estimates were calculated by the validated equations. At baseline, higher levels of specific BA subtypes were related to higher levels of atherogenic VLDL lipid subtypes and ASCVD risk estimates. Weight-loss diet-induced decreases in primary BAs were related to larger reductions of triglycerides and total cholesterol (every 1-SD decrease of glycocholate, glycochenodeoxycholate, or taurochenodeoxycholate was related to β [SE] –3.3 [1.3], –3.4 [1.3], or –3.8 [1.3] mg/dl, respectively; PFDR <0.05 for all). Greater decreases in specific secondary BA subtypes were also associated with improved lipid metabolism at 6 months; there was β –4.0 [1.1] mg/dl per 1-SD decrease of glycoursodeoxycholate (PFDR=0.003) for changes in LDL cholesterol. We found significant interactions (Pinteraction <0.05) between dietary fat intake and changes in BA subtypes on cha...