Cognition and Memory after Covid-19 in a Large Community Sample

作者：Adam Hampshire, Adriana Azor, Christina Atchison, William Trender, Peter J. Hellyer, Valentina Giunchiglia, Masud Husain, Graham Cooke, Emily Cooper, Adam Lound, Christl A. Donnelly, Marc Chadeau‐Hyam, Helen Ward, Paul Elliott · 发表于：New England Journal of Medicine · 年份：2024 · DOI：10.1056/nejmoa2311330 · 被引用次数：257 · 研究领域：Long-Term Effects of COVID-19、COVID-19 and Mental Health、Dementia and Cognitive Impairment Research

BACKGROUND: Cognitive symptoms after coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are well-recognized. Whether objectively measurable cognitive deficits exist and how long they persist are unclear. METHODS: We invited 800,000 adults in a study in England to complete an online assessment of cognitive function. We estimated a global cognitive score across eight tasks. We hypothesized that participants with persistent symptoms (lasting ≥12 weeks) after infection onset would have objectively measurable global cognitive deficits and that impairments in executive functioning and memory would be observed in such participants, especially in those who reported recent poor memory or difficulty thinking or concentrating ("brain fog"). RESULTS: Of the 141,583 participants who started the online cognitive assessment, 112,964 completed it. In a multiple regression analysis, participants who had recovered from Covid-19 in whom symptoms had resolved in less than 4 weeks or at least 12 weeks had similar small deficits in global cognition as compared with those in the no-Covid-19 group, who had not been infected with SARS-CoV-2 or had unconfirmed infection (-0.23 SD [95% confidence interval {CI}, -0.33 to -0.13] and -0.24 SD [95% CI, -0.36 to -0.12], respectively); larger deficits as compared with the no-Covid-19 group were seen in participants with unresolved persistent symptoms (-0.42 SD; 95% CI, -0.53 to -0.31). Lar...