The alleviating effect of Akkermansia muciniphila PROBIO on AOM/DSS-induced colorectal cancer in mice and its regulatory effect on gut microbiota

作者：Xin Ma, LvjunYan, Xueping Yu, Hui Guo, Yongpeng He, Shufan Wen, Ting Yu, Wei Wang · 发表于：Journal of Functional Foods · 年份：2024 · DOI：10.1016/j.jff.2024.106091 · 被引用次数：21 · 研究领域：Gut microbiota and health、Probiotics and Fermented Foods、Immune Response and Inflammation

Emerging evidence indicates that Akkermansia muciniphila (AKK) may be a potential probiotic agent for ameliorating colorectal cancer (CRC). Thus, we utilized the azoxymethane (AOM)/ dextran sodium sulfate (DSS)-induced mouse model of colorectal cancer to evaluate the intervention effect of AKK PROBIO. The results showed that AKK PROBIO significantly improved mouse colon health, decreased the serum pro-inflammatory cytokines levels, as well as downregulated the mRNA levels of p50, p52, p65, and IκBβ, upregulated the expressions of Bid, Bim, and caspase-9 in the colon. In addition, AKK PROBIO modulated the gut microbiota composition, as characterized by the increased abundance of Muribaculaceae and Akkermansia and the decreased levels of Bacteroides, and Parasutterella. Notably, the high-dosage group was better than that of low-dosage. In conclusion, AKK PROBIO has the potential to modulate colorectal cancer by alleviating intestinal inflammation through the NF-κB pathway and promoting cell apoptosis, thereby intervening in the development of colorectal tumors.