Ultrasound-augmented cancer immunotherapy

作者：Bingjie Liu, Fangxue Du, Ziyan Feng, Xiang Xi, Ruiqian Guo, Lang Ma, Bihui Zhu, Li Qiu · 发表于：Journal of Materials Chemistry B · 年份：2024 · DOI：10.1039/d3tb02705h · 被引用次数：21 · 研究领域：Cancer Immunotherapy and Biomarkers、Nanoplatforms for cancer theranostics、Immunotherapy and Immune Responses

Cancer is a growing worldwide health problem with the most broadly studied treatments, in which immunotherapy has made notable advancements in recent years. However, innumerable patients have presented a poor response to immunotherapy and simultaneously experienced immune-related adverse events, with failed therapeutic results and increased mortality rates. Consequently, it is crucial to develop alternate tactics to boost therapeutic effects without producing negative side effects. Ultrasound is considered to possess significant therapeutic potential in the antitumor field because of its inherent characteristics, including cavitation, pyrolysis, and sonoporation. Herein, this timely review presents the comprehensive and systematic research progress of ultrasound-enhanced cancer immunotherapy, focusing on the various ultrasound-related mechanisms and strategies. Moreover, this review summarizes the design and application of current sonosensitizers based on sonodynamic therapy, with an attempt to provide guidance on new directions for future cancer therapy.