REDISCOVER International Guidelines on the Perioperative Care of Surgical Patients With Borderline-resectable and Locally Advanced Pancreatic Cancer

作者：Ugo Boggi, Emanuele F. Kauffmann, Niccolò Napoli, Savio George Barreto, Marc G. Besselink, Giuseppe Fusai, Thilo Hackert, Mohammad Abu Hilal, Giovanni Marchegiani, Roberto Salvia, Shailesh V. Shrikhande, Mark Joseph Truty, Jens Werner, Christopher Lee Wolfgang, Elisa Bannone, Giovanni Luigi Capretti, Alice Cattelani, Alessandro Coppola, Alessandro Cucchetti, Davide De Sio, Armando Di Dato, Giovanna Di Meo, Claudio Fiorillo, Cesare Gianfaldoni, Michael Ginesini, Camila Hidalgo Salinas, Quirino Lai, Mario Miccoli, Roberto Maria Montorsi, Michele Pagnanelli, Andrea Poli, Claudio Ricci, Francesco Sucameli, Domenico Tamburrino, Virginia Viti, Pietro Addeo, Sergio Alfieri, Philippe Bachellier, Gian Luca Baiocchi, Gianpaolo Balzano, Linda Barbarello, Alberto Brolese, Juli Busquets, Giovanni Butturini, Fabio Caniglia, Damiano D. Caputo, Riccardo Casadei, Xi Chunhua, Ettore Colangelo, Andrea Coratti, Francesca Costa, Francesco Crafa, Raffaele Dalla Valle, Luciano G. De Carlis, Roeland F. de Wilde, Marco Del Chiaro, Fabrizio Di Benedetto, Pierluigi Di Sebastiano, Safi Domak, Melissa Ellen Hogg, V. Egorov, Giorgio Ercolani, Giuseppe Maria Ettorre, Massimo Falconi, Giovanni Carlo Ferrari, Alessandro Ferrero, Marco Filauro, Alessandro Giardino, Gian Luca Grazi, Salvatore Gruttaduaria, Jakob Robert Izbicki, Elio Jovine, Matthew H. G. Katz, Tobias Keck, Igor E Khatkov, Gozo Kiguchi, David A. Kooby, Hauke Lang, Carlo Lombardo, Giuseppe Malleo, Marco Massani, Vincenzo Mazzaferro, Riccardo Memeo, Yi Miao, Kohei Mishima, Carlo Molino, Yuichi Nagakawa, Masafumi Nakamura, Bruno Nardo, Fabrizio Panaro, Claudio Pasquali, Vittorio Perrone, Elena B. Rangelova, Rong Liu, Renato Romagnoli, Raffaele Romito, Edoardo Rosso, Richard David Schulick, Ajith Kumar Siriwardena, Marcello Giuseppe Spampinato, Oliver Strobel, Mario Testini, Roberto Ivan Troisi, Faik G Uzunoglo, Umberto Valente, Luigi Veneroni, Alessandro Zerbi, Emilio Vicente, Fabio Vistoli, Marco Vivarelli, Go Wakabayashi, Giacomo Zanus, Amer H. Zureikat, Nicholas Joseph Zyromski, Roberto Coppola, Vito D’Andrea, José Davide, Christos Dervenis, Isabella M. Frigerio, Kevin C. Konlon, Fabrizio Michelassi, Marco Montorsi, William H. Nealon, Nazario Portolani, Donzília Sousa Silva, Giuseppe Bozzi, Viviana Nicoleta Ferrari, Maria Giovanna Trivella, John L. Cameron, Pierre‐Alain Clavien, Horacio J. Asbun, The REDISCOVER Multidisciplinary Advisory Board · 发表于：Annals of Surgery · 年份：2024 · DOI：10.1097/sla.0000000000006248 · 被引用次数：67 · 研究领域：Pancreatic and Hepatic Oncology Research、Cancer, Stress, Anesthesia, and Immune Response、Pancreatitis Pathology and Treatment

OBJECTIVE: The REDISCOVER consensus conference aimed at developing and validating guidelines on the perioperative care of patients with borderline-resectable (BR-) and locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC). BACKGROUND: Coupled with improvements in chemotherapy and radiation, the contemporary approach to pancreatic surgery supports the resection of BR-PDAC and, to a lesser extent, LA-PDAC. Guidelines outlining the selection and perioperative care for these patients are lacking. METHODS: The Scottish Intercollegiate Guidelines Network (SIGN) methodology was used to develop the REDISCOVER guidelines and create recommendations. The Delphi approach was used to reach a consensus (agreement ≥80%) among experts. Recommendations were approved after a debate and vote among international experts in pancreatic surgery and pancreatic cancer management. A Validation Committee used the AGREE II-GRS tool to assess the methodological quality of the guidelines. Moreover, an independent multidisciplinary advisory group revised the statements to ensure adherence to nonsurgical guidelines. RESULTS: Overall, 34 recommendations were created targeting centralization, training, staging, patient selection for surgery, possibility of surgery in uncommon scenarios, timing of surgery, avoidance of vascular reconstruction, details of vascular resection/reconstruction, arterial divestment, frozen section histology of perivascular tissue, extent of lymphadenectomy, anticoagulation pr...