Multiple influence of immune cells in the bone metastatic cancer microenvironment on tumors

作者：Shixin Chen, Jiangchu Lei, Haochen Mou, Wenkan Zhang, Lingxiao Jin, Senxu Lu, Eloy Yinwang, Yucheng Xue, Zhenxuan Shao, Tao Chen, Fangqian Wang, Shenzhi Zhao, Xupeng Chai, Zenan Wang, Jiahao Zhang, Zengjie Zhang, Zhaoming Ye, Binghao Li · 发表于：Frontiers in Immunology · 年份：2024 · DOI：10.3389/fimmu.2024.1335366 · 被引用次数：25 · 研究领域：Immune cells in cancer、Cancer Immunotherapy and Biomarkers、Cancer Cells and Metastasis

constitute a unique immune microenvironment, which plays a crucial role in the context of bone metastasis. This review firstly focuses on lymphatic cells in bone metastatic cancer, including their function in tumor dissemination, invasion, growth and possible cytotoxicity-induced eradication. Subsequently, we examine myeloid cells, namely macrophages, myeloid-derived suppressor cells, dendritic cells, and megakaryocytes, evaluating their interaction with cytotoxic T lymphocytes and contribution to bone metastasis. As important components of skeletal tissue, osteoclasts and osteoblasts derived from bone marrow stromal cells, engaging in 'vicious cycle' accelerate osteolytic bone metastasis. We also explain the concept tumor dormancy and investigate underlying role of immune microenvironment on it. Additionally, a thorough review of emerging treatments for bone metastatic malignancy in clinical research, especially immunotherapy, is presented, indicating current challenges and opportunities in research and development of bone metastasis therapies.