Abnormal Static and Dynamic Local Functional Connectivity in First-Episode Schizophrenia: A Resting-State fMRI Study

作者：Jie Zhou, Xiong Jiao, Qiang Hu, Lizhao Du, Jijun Wang, Junfeng Sun · 发表于：IEEE Transactions on Neural Systems and Rehabilitation Engineering · 年份：2024 · DOI：10.1109/tnsre.2024.3368697 · 被引用次数：8 · 研究领域：Functional Brain Connectivity Studies、Advanced MRI Techniques and Applications、Neural dynamics and brain function

Dynamic functional connectivity (FC) analyses have provided ample information on the disturbances of global functional brain organization in patients with schizophrenia. However, our understanding about the dynamics of local FC in never-treated first episode schizophrenia (FES) patients is still rudimentary. Dynamic Regional Phase Synchrony (DRePS), a newly developed dynamic local FC analysis method that could quantify the instantaneous phase synchronization in local spatial scale, overcomes the limitations of commonly used sliding-window methods. The current study performed a comprehensive examination on both the static and dynamic local FC alterations in FES patients (N = 74) from healthy controls (HCs, N = 41) with resting-state functional magnetic resonance imaging using DRePS, and compared the static local FC metrics derived from DRePS with those calculated from two commonly used regional homogeneity (ReHo) analysis methods that are defined based on Kendall's coefficient of concordance (KCC-ReHo) and frequency coherence (Cohe-ReHo). Symptom severities of FES patients were assessed with a set of clinical scales. Cognitive functions of FES patients and HCs were assessed with the MATRICS consensus cognitive battery. Group-level analysis revealed that compared with HCs, FES patients exhibited increased static local FC in right superior, middle temporal gyri, hippocampus, parahippocampal gyrus, putamen, and bilateral caudate nucleus. Nonetheless, the dynamic local FC metrics ...