Effects of Pitavastatin on Coronary Artery Disease and Inflammatory Biomarkers in HIV

作者：Michael T. Lu, Heather J. Ribaudo, Borek Foldyna, Markella V. Zanni, Thomas Mayrhofer, Júlia Karády, Jana Taron, Kathleen V. Fitch, Sara McCallum, Tricia H. Burdo, Kayla Paradis, Sandeep Hedgire, Nandini M. Meyersohn, Christopher R. deFilippi, Carlos Malvestutto, A. Sturniolo, Marissa R Diggs, Sue Siminski, Gerald S. Bloomfield, Beverly Alston‐Smith, Patrice Desvigne‐Nickens, Edgar T. Overton, Judith S. Currier, Judith A. Aberg, Carl J. Fichtenbaum, Udo Hoffmann, Pamela S. Douglas, Steven Grinspoon, REPRIEVE Trial Writing Group, Carl J. Fichtenbaum, Judith A. Aberg, Eric S. Daar, Babafemi Taiwo, Susan L. Koletar, Kara W Chew, Susan J. Little, Sonya L. Heath, Jeffrey M. Jacobson, Rajesh T. Gandhi, Gregory K. Robbins, Rachel M. Presti, Marshall J. Glesby, Annie Luetkemeyer, Pablo Tebas, Sharon A. Riddler, Michael P. Dubé, Jorge Santana‐Bagur, Beverly E. Sha, Jennifer Manne‐Goehler, Roberto C. Arduino, Charles Flexner, David W. Haas, David A. Wohl, Magdalena E. Sobieszczyk, Karen T. Tashima, Sonal S. Munsiff, Rachel Bender Ignacio, Kristen Marks, Cornelius Van Dam, Shobha Swaminathan, Thomas Campbell, Beverly Alston‐Smith, Patricia W Bandettini, Gerald S. Bloomfield, Judith S. Currier, Patrice Desvigne-Nickens, Marissa R Diggs, Pamela S. Douglas, Kathleen V. Fitch, Steven Grinspoon, Peter Kim, Michael T. Lu, Kayla Paradis, Heather J. Ribaudo, Yves Rosenberg, James Troendle, Mark Byroads, Elaine S. Gershman, Folake Lawal, Jorge Leon-Cruz, Rochelle Louis, Cheryl Lowe, Eva Moy, Triin Umbleja, Namrata Upadhyay, Stephen D. Wiviott, Kenneth W. Wood, O. Igwegbe Anthony, Radhika Barve, Fred Bone, Selina Bannoo, Annie Duffy, Carl Fletcher, M V Green, Nory Klop‐Packel, Sara McCallum, Emilia Norton, Jennifer Nowak, Maria Sanchez Grande, Sue Siminski, Eloise Walker, David Vlieg, Tricia H. Burdo, Laura Moran, Jhoanna Roa, Heather Sprenger, Bola Adedeji, Oladapo Alli, Blanca Toledo del Castillo, Joan Dragavon, K. Jack Easley, Julian Falutz, Ewelinka Grzejka, Erin Hoffman, Yuji Liao, Sara E. Looby, Dana Nohynek, Mary McCurdy Pate, James F. Rooney, Akbar Shahkolahi, Craig A. Sponseller, Kenneth C. Williams, Markella V. Zanni, Kate Borloglou, Meredith E. Clement, Allison Ross Eckard, Rebecca LeBlanc, Carlos Malvestutto, Edgar T. Overton, Karl Shaw, Virginia A. Triant, Amy Kantor, Jennifer Manne‐Goehler, Kate Starr, Ronald L. Barnett, Jane Baum, Cindy Coates, Sandra W. Cordoso, Christie Lyn Costanza, Sylvia Davila, Dushyantha Jayaweera, Teri Greenfield, Howard Gutzman, Regina Harden, Sarah Henn, MJ Humphries, Mamta K. Jain, David C. Klein, Sharon Kohrs, Javier R. Lama, Jessica Landis, Jaclyn Leone, Rita Lira, Marı́a Elena Martı́nez, Richard Novák, Karen Reese, Breno Santos, Jenese Tucker, Aimee Wilkin, T Wilson, Borek Foldyna, Júlia Karády, Thomas Mayrhofer, Audra Sturniolo, Barbara Bastow, Françoise Giguel, Nada Saleh, John W. Ward, Erin Cherban, Sean S. Brummel, Janeway Granche, Carlee Moser, Pawel Paczuski, Laura Smeaton, Claire Benjamin, Tanisha Cadet, Evelynne S. Fulda, Jacqueline Murphy, Alicia Diggs, Robert S. Ettinger, Ángel Goyenechea Hernández, Janice Jarrells, Shirley Selvage, Sandeep Hedgire, Udo Hoffman, Nina Meyersohn, Jana Taron, Anthony Holguin, Gregory Pavlov, Scott Hammer, Martin Hirsch, JoAnn Manson, Paul M. Ridker, James H. Stein, Russell P. Tracy, James E. Udelson, Estebán Martínez, Tim Leaver, Anton Pozniak, Kathy Melbourne, Matthew J. Budoff, Ben Cheng, Sara F. Goldkind, Carl Grünfeld, Robert Harrington, Donald M. Lloyd‐Jones, Jennifer G. Robinson, Lynn A. Sleeper, George Sopko, Paul A. Volberding, Fassil Ketema, Karin L. Klingman, Keisha Johnson, Mark M. Mishkin, Daniella Livnat, Akin Ojumu, Alba Sierto · 发表于：JAMA Cardiology · 年份：2024 · DOI：10.1001/jamacardio.2023.5661 · 被引用次数：86 · 研究领域：HIV-related health complications and treatments、Lipoproteins and Cardiovascular Health、Cardiovascular Disease and Adiposity

Importance: Cardiovascular disease (CVD) is increased in people with HIV (PWH) and is characterized by premature noncalcified coronary plaque. In the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE), pitavastatin reduced major adverse cardiovascular events (MACE) by 35% over a median of 5.1 years. Objective: To investigate the effects of pitavastatin on noncalcified coronary artery plaque by coronary computed tomography angiography (CTA) and on inflammatory biomarkers as potential mechanisms for MACE prevention. Design, Setting, and Participants: This double-blind, placebo-controlled randomized clinical trial enrolled participants from April 2015 to February 2018 at 31 US clinical research sites. PWH without known CVD who were taking antiretroviral therapy and had low to moderate 10-year CVD risk were included. Data were analyzed from April to November 2023. Intervention: Oral pitavastatin calcium, 4 mg per day. Main Outcomes and Measures: Coronary CTA and inflammatory biomarkers at baseline and 24 months. The primary outcomes were change in noncalcified coronary plaque volume and progression of noncalcified plaque. Results: Of 804 enrolled persons, 774 had at least 1 evaluable CTA. Plaque changes were assessed in 611 who completed both CT scans. Of 611 analyzed participants, 513 (84.0%) were male, the mean (SD) age was 51 (6) years, and the median (IQR) 10-year CVD risk was 4.5% (2.6-7.0). A total of 302 were included in the pitavastatin arm and 309 in the place...