Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics

作者：Volker Gerke, Felicity N. E. Gavins, Michael J. Geisow, Thomas Grewal, Jyoti K. Jaiswal, Jesper Nylandsted, Ursula Rescher · 发表于：Nature Communications · 年份：2024 · DOI：10.1038/s41467-024-45954-0 · 被引用次数：147 · 研究领域：S100 Proteins and Annexins、Neuroscience of respiration and sleep、Connexins and lens biology

Abstract Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic phospholipids in cellular membranes at elevated Ca2+levels. Through this they act as Ca2+-regulated membrane binding modules that organize membrane lipids, facilitating cellular membrane transport but also displaying extracellular activities. Recent discoveries highlight annexins as sensors and regulators of cellular and organismal stress, controlling inflammatory reactions in mammals, environmental stress in plants, and cellular responses to plasma membrane rupture. Here, we describe the role of annexins as Ca2+-regulated membrane binding modules that sense and respond to cellular stress and share our view on future research directions in the field.