Viral and Host Factors Are Associated With Mortality in Hospitalized Patients With COVID-19

作者：Neil R. Aggarwal, Jacquie Nordwall, Dominique L. Braun, Lucy Chung, Jordan Coslet, Tatyana Der, Nnakelu Eriobu, Adit A. Ginde, Awori J. Hayanga, Helene Highbarger, Mark Holodniy, Juan Pablo Horcajada, Mamta K. Jain, Kami Kim, Sylvain Laverdure, Jens Lundgren, Ven Natarajan, Hien Nguyen, Sarah Pett, Andrew Phillips, Garyphallia Poulakou, David Price, Philip A. Robinson, Angela J Rogers, Uriel Sandkovsky, Katy Shaw-Saliba, Jeffrey M. Sturek, Barbara W. Trautner, Michael R. Waters, Cavan Reilly, for the ACTIV-3/TICO Study Group, David Sahner, John Tierney, Susan Vogel, Betsey Herpin, Mary Smolskis, Laura A McKay, Kelly Cahill, Page Crew, Ratna Sardana, Sharon Segal Raim, Lisa Hensely, J. Ponce Lorenzo, Rebecca Mock, Judith Zuckerman, Negin Atri, Mark D. Miller, David Vallée, Lucy Chung, Nayon Kang, Kevin Barrett, Stacey J. Adam, Sarah Read, Ruxandra Draghia‐Akli, Judy Currier, Eric Hughes, Rachel H. Harrigan, Laura Amos, Amy Carlsen, Anita Carter, Gary Collins, Bionca Davis, Eileen Denning, Alain DuChêne, Kate Eckroth, Nicole Engen, Alex Frase, Greg Gandits, Birgit Grund, Merrie Harrison, Nancy Hurlbut, Payton Kaiser, Joseph S. Koopmeiners, Gregg Larson, Sue Meger, Shweta Sharma Mistry, Thomas A. Murray, Ray Nelson, Kien Quan, Siu Fun Quan, Cavan Reilly, Lianne Siegel, Greg Thompson, David M. Vock, Jamie Walski, Annetine C. Gelijns, Alan J. Moskowitz, Emilia Bagiella, Ellen Moquete, Karen O'Sullivan, Mary E. Marks, Evan Accardi, Emily Kinzel, Sarah Burris, Gabriela Bedoya, Lola Gupta, Jessica Overbey, Milerva Santos, Marc A. Gillinov, Marissa A. Miller, Wendy C. Taddei‐Peters, Kathleen N. Fenton, Uriel Sandkovsky, Robert Gottlieb, M. Mack, Mezgebe Berhe, Clinton Haley, Emma Dishner, Christopher Bettacchi, Kevin Golden, Erin Duhaime, Madison Ryan, Sarah Burris, Catherine Tallmadge, Lorie Estrada, Felecia Jones, Samatha Villa, Samatha Wang, Raven Robert, Tanquinisha Coleman, Laura Clariday, Rebecca Baker, Mariana Hurutado-Rodriguez, Nazia Iram, Michelle Fresnedo, Allyson Davis, Kiara Leonard, Noelia Ramierez, Jon Thammavong, Krizia Duque, Emma Turner, Fisher Tammy, Dianna Robinson, Desirae Ransom, Nicholas Maldonado, Erica Lusk, Aaron Killian, Palacious Adriana, Edilia Solis, Janet Jerrow, Matthew Watts, Heather Whitacre, Elizabeth Cothran, Peter K. Smith, Christina E. Barkauskas, Andrew M. Vekstein, Emily R. Ko, Grace R. Dreyer, Neil Stafford, Megan Brooks, Tatyana Der, Marie Witte, Ruwan Gamarallage, John Franzone, Noel Ivey, Rebecca Lumsden, Nilima Mosaly, Ahmaad Mourad, Thomas L Holland, Mary Motta, Kathleen Lane, Lauren M McGowan, Jennifer Stout, Heather Aloor, Kennesha M. Bragg, Barvina Toledo, Beth McLendon-Arvik, Barbara Bussadori, Beth Hollister, Michelle Griffin, Dana M. Giangiacomo, Vicente Martínez Rodríguez, Gordon Bokhart, Sharon M. Eichman, Patrick E. Parrino, Stephen M. Spindel, Aditya Bansal, Katherine Baumgarten, Johnathan Hand, Derek J. Vonderhaar, Bobby D. Nossaman, Sylvia Laudun, DeAnna Ames, Shane Broussard, Nilmo Hernandez, Geralyn Isaac, Huan Dinh, Yiling Zheng, Sonny Tran, Hunter McDaniel, Nicolle Crovetto, Emerson C. Perin, Briana Costello, Prasad Manian, M. Rizwan Sohail, Alexander Postalian, Punit Hinsu, Carolyn Watson, James Chen, Melyssa Fink, Lydia Sturgis, Kim Walker, Kim Mahon, Jennifer Parenti, Casey Kappenman, Aryn Knight, Jeffrey M Sturek, Andrew Barros, Kyle B Enfield, Alexandra Kadl, China J. Green, Rachel M. Simon, Ashley Fox, Kara J Thornton, Amy Adams, Vinay Badhwar, Sunil Sharma, Briana Peppers, Paul McCarthy, Troy Krupica, Arif R Sarwari, Rebecca Reece, Lisa Fornaresico, Chad Glaze, Raquel Evans, Di Fang, Shawn Carlson, Tanja Aucremanne, Connie S. Tennant, Sutton Lisa Giblin, Sabrina Buterbaugh, Roger A. Williams, Robin Bunner, Jay H. Traverse, Frank S. Rhame, Joshua Huelster, Rajesh Kethireddy, Irena Davies, Julianne Salamanca, Christine Majeski, Paige Skelton, Maria Zarambo, Andrea Sarafolean, Michael E. Bowdish, Zea Borok, Noah Wald‐Dickler, Douglass Hutcheon, Amytis Towfighi, Mary Lee, Meghan Lewis, Brad Spellberg, Linda Sher, Aniket Sharma, Anna Olds, Chris Justino, Edward Loxano, Chris Romero, Janet Leong, V. I. Rodina, Christine Quesada, Luke Hamilton, José J. Escobar, Brad Leshnower, William Bender, Milad Sharifpour, Jeffrey J. Miller, Woodrow J. Farrington, Kim T. Baio, Mary L. McBride, Michele Fielding, Sonya Mathewson, Kristina Porte, Missy Maton, Chari Ponder, Elisabeth Haley, Christine Spainhour, Susan Rogers, Derrick Tyler, Ronson J. Madathil, Joseph Rabin, Andrea R. Levine, Kapil Saharia, Ali Tabatabai, Christine Lau, James S. Gammie, Maya-Loren Peguero, Kimberly McKernan, Mathew Audette, Emily Fleischmann, Kreshta Akbari, Myoung-Hee Lee, Andrew Chi, Hanna Salehi, Alan Pariser, Phuong Tran Nyguyen, Jessica Moore, Adrienne Gee, Shelika Vincent, Richard A. Zuckerman, Alexander Iribarne, Sara Metzler, Samantha Shipman, Haley Johnson, Crystallee Newton, Doug Parr, Leslie Miller, Beth Schelle, Sherry McLean, Howard R. Rothbaum, Michael S. Alvarez, Shivam Kalan, Heather H. Germann, Jennifer Hendershot, Karen Moroney, Karen Herring, Sharri Cook, Pam Paul, Rebecca Walker-Ignasiak, Crystal M. North, Cathryn F. Oldmixon, Nancy Ringwood, Ariela Muzikansky, Richard P. Morse, Laura Fitzgerald, Haley Morin, Roy G. Brower, Lora A. Reineck, Karen Bienstock, Jay Steingrub, Peter Hou, Jay S. Steingrub, Mark Tidswell, Lori-Ann Kozikowski, Cynthia Kardos, Leslie DeSouza, Sarah Romain, Sherell Thornton‐Thompson, Daniel Talmor, Nathan I. Shapiro, Konstantinos Andromidas, Valerie Banner‐Goodspeed, Michael Bolstad, Katherine L. Boyle, Payton Cabrera, Arnaldo deVilla, Joshua C Ellis, Ana Grafals, Sharon Hayes, Conor Higgins, Lisa Kurt, Nicholas Kurtzman, Kimberly Redman, Elinita Rosseto, Douglas Scaffidi, Nathan I. Shapiro, Michael R. Filbin, Kathryn A. Hibbert, Blair A. Parry, Justin Margolin, Brooklynn Hillis, Rhonda Hamer, Kelsey Brait, Caroline Beakes, Brenna McKaig, Eleonore Kugener, Alan E. Jones, James Galbraith, Utsav Nandi, Rebekah Peacock, Gregory Hendey, Kirsten N. Kangelaris, Kimia Ashktorab, Rachel Gropper, Anika Agrawal, K Yee, Alejandra E. Jauregui, Hanjing Zhuo, Eyad Almasri, Mohamed Fayed, Kinsley Hubel, Alyssa Hughes, Rebekah L. Garcia, George Lim, Steven Y. Chang, Gregory Hendey, Michael Lin, Julia Vargas, Hena Sihota, Rebecca M. Beutler, Trisha Agarwal, Jennifer G. Wilson, Rosemary Vojnik, Cynthia Pérez, Jordan H. McDowell, Jonasel Roque, Henry E. Wang, Ryan Huebinger, Bela Patel, Elizabeth Vidales, Timothy E. Albertson, Erin Hardy, Richart W. Harper, M.A. Moss, Amiran Baduashvili, Lakshmi Chauhan, David J. Douin, Flora Martinez, Lani Finck, Jill Bastman, Michelle Howell, Carrie Higgins, Jeffrey McKeehan, Jay Finigan, Peter Stubenrauch, William J. Janssen, Christine Griesmer, Olivia VerBurg, Robert C. Hyzy, Pauline K. Park, Kristine Nelson, J.I. Mcsparron, Ivan Co, Bonnie R. Wang, José Jimenez, Norman Olbrich, Kelli McDonough, Shijing Jia, Sinan Hanna, Michelle N. Gong, Lynne D. Richardson, Rahul Nair, Brenda López, Omowunmi Amosu, Obiageli Offor, Hiwet Tzehaie, William Nkemdirim, Sabah Boujid, Jarrod Mosier, Cameron Hypes, Elizabeth Salvagio Campbell, Billie Bixby, Boris Gilson, Anitza Lopez, Christian Bime, Sairam Parthasarathy, Ariana M Cano, R. Duncan Hite, Thomas E. Terndrup, Herbert Wiedemann, Kristin Hudock, Hammad Tanzeem, Harshada More, Jamie Martinkovic, Susan Sellers, Judy Houston, Mary Burns, Simra Kiran, Tammy Roads, Sarah Kennedy, Abhijit Duggal, Nirosshan Thiruchelvam, Kiran Ashok, Alexander H. King, Omar Mehkri, Siddharth Dugar, Debasis Sahoo, Donald M. Yealy, Derek Angus, Alexandra Weissman, Tina Vita, Emily Berryman, Catherine L. Hough, Akram Khan, Olivia Krol, Emmanuel Mills, Mistry Kinjal, Genesis Briceño, Raju Reddy, Kinsley Hubel, Milad Karami Jouzestani, Madeline McDougal, Rupali Deshmukh, Nicholas J Johnston, Bryce H. Robinson, Staphanie J Gundel, Sarah C. Katsandres, Peter Chen, Sam Torbati, Tanyalak Parimon, Antonina Caudill, Brittany Mattison, Susan Jackman, Po-En Chen, Emad Bayoumi, Cristabelle Ojukwu, Devin Fine, Gwendolyn Weissberg, Katherine Isip, Yunhee Choi-Kuaea, Shaunt Mehdikhani, Tahir B Dar, Nsole Biteghe Fleury Augustin, Dana Tran, Jennifer Dukov, Yuri Matusov, June Choe, Niree Hindoyan, Timothy Wynter, Ethan Pascual, Gregg J. Clapham, Lisa Herrera, Antonia Caudill, D. Shane O’Mahony, Sonam T. Nyatsatsang, David M. Wilson, Julie A. Wallick, Alexandria M. Duven, Dakota D. Fletcher, Chadwick Miller, D. Clark Files, Kevin W. Gibbs, Lori Flores, Mary LaRose, Leigha Landreth, D. Rafael Palacios, Lisa Parks, Madeline Hicks, Andrew Goodwin, Edward F. Kilb, Caitlan Lematty, Kerilyn Patti, Abigail Grady, April Rasberry, Peter E. Morris, Jamie Sturgill, Evan Cassity, Sandipan Dhar, Ashley Montgomery-Yates, Sarah N Pasha, Kirby P. Mayer, Brittany Bissel, Terren Trott, Shahnaz Rehman, Wit Marjolein de, Jessica Mason, Joseph Bledsoe, Kirk U. Knowlton, Samuel M. Brown, Michael J. Lanspa, Lindsey Leither, Ithan Pelton, Brent Armbruster, Quinn Montgomery, Naresh Kumar, Melissa Fergus, Karah Imel, Ghazal Palmer, Brandon Webb, Carolyn Klippel, Hannah Jensen, Sarah Duckworth, Andrew Gray, Tyler Burke, Dan Knox, Jenna Lumpkin, Valerie Aston, Darrin Applegate, Erna Serezlic, Katie Brown, Mardee Merril, Estelle S. Harris, Elizabeth A. Middleton, Macy A G Barrios, Jorden Greer, Amber D. Schmidt, Melissa K. Webb, Roert Paine, Sean J. Callahan, Lindsey Waddoups, Misty B. Yamane, Wesley H. Self, Todd W. Rice, Jonathan D. Casey, Jakea Johnson, Christopher Gray, Margaret Hays, Megan Roth, Vidya Menon, Moiz Kasubhai, Anjana Pillai, Jean Daniel, Daniel Sittler, Balavenkatesh Kanna, Nargis Jilani, Francisco Amaro, Jessica Santana, Aleksandr Lyakovestsky, Issa Madhoun, Louis Marie Desroches, Nicole Amadon, Alaa Bahr, Imaan Ezzat, Maryanne Guerrero, Joane Padilla, Jessie Fullmer, Inderpreet Singh, Syed Shah, Rajeev Narang, Polly Mock, Melissa Shadle, Brenda Y. Hernandez, Kevin D. Welch, Andrea Payne, Gabriela Ertl, Daniel Canario, Isabel Barrientos, Danielle Goss, Mattie DeVries, Ibidolapo Folowosele, Dorothy Garner, Mariana Gómez, Justin Price, Ekta Bansal, Jim Wong, Jason Faulhaber, Tasaduq Fazili, Brian Yeary, Ruth Ndolo, Christina Bryant, Bridgette Smigeil, Philip A. Robinson, Rana Najjar, Patrice Jones, Julie Nguyen, Christina Chin, Hassan Taha, Salah Najm, Chris Smith, Jason H. Moore, Talal Nassar, Nick Gallinger, Amy Christian, D’Amber Mauer, Ashley Phipps, Michael R. Waters, Karla Zepeda, Jordan Coslet, Rosalynn Landazuri, Jacob Pineda, Nicole Uribe, Jose Ruiz Garcia, Cecilia Barbabosa, Kaitlyn Sandler, J. Scott Overcash, Adrienna Marquez, Hanh Chu, Kia Lee, Kimberly Quillin, Andrea Arnaiz García, Pauline Lew, Ralph Rogers, Fadi Shehadeh, Evangelia K. Mylona, Matthew Kaczynski, Quynh-Lam Tran, Gregorio Benitez, Biswajit Mishra, Lewis Oscar Felix, Maria Tsikala Vafea, Eleftheria Atalla, Robin Davies, Salma Hedili, Maria Andrea Monkeberg, Sandra Tabler, Britt Harrington, Meegada Sreenath, Venkata Sandeep Koripalli, Prithvi Muddana, Lakshay Jain, Chaitanya Undavalli, Parasa Kavya, Mofoluwaso Ibiwoye, Hameed Akilo, Bryce D Lovette, Jamie-Crystal Wylie, Diana M. Smith, Kenneth K. Poon, Paula Eckardt, Rubio-Gomez Heysu, Nithya Sundararaman, Doris Alaby, Candice Sareli, Adriana Sánchez, L. Popielski, Amy Kambo, Kimberley Viens, Melissa Turner, Michael J. Vjecha, Amy Weintrob, Indira Brar, Norman Markowitz, Erika Pastor, Roweena Corpuz, George Alangaden, John E. McKinnon, Mayur Ramesh, Erica Herc, Nicholas Yared, Lanfranco Odaliz Abreu, Emanuel P. Rivers, Jennifer Swiderek, Gupta Ariella Hodari, Pardeep Pabla, Sonia Eliya, Jehan Jazrawi, Jeremy Delor, Mona Desai, Aaron M. Cook, Jaehne Anja Kathrina, Gill Jasreen Kaur, Sheri Renaud, Siva Sarveswaran, Edward M. Gardner, James A. Scott, Monica Bianchini, Casey Melvin, Gina Kim, David Wyles, Kevin Kamis, Rachel G. Miller, Ivor S. Douglas, Jason S. Haukoos, Carrie Hicks, Susana Lazarte, Rubria Marines‐Price, Alice Osuji, Barbine Tchamba Agbor Agbor, Tianna Petersen, Dena Kamel, Laura Hansen, Angie Garcia, Christine Cha, Azadeh Mozaffari, Rosa Marı́a Hernández, James B Cutrell, Barbine Tchamba Agbor Agbor, Mi‐Na Kim, Natalie DellaValle, S. Jake Gonzales, Charurut Somboonwit, Asa Oxner, Lucy Guerra, M. Hayes, Thi H. O. 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Jensen, Birgitte Lindegaard Madsen, Thomas Ingemann Pedersen, Zitta Barrella Harboe, Birgit Thorup Røge, Thomas Michael Hansen, Matilde Kanstrup Glesner, Sandra Valborg Løfberg, Ariella Denize Nielsen, von Huth Sebastian Leicht, Henrik Nielsen, Rikke Krog Thisted, Kristine Toft Petersen, Maria Ruwald Juhl, Daria Podlekareva, Stine Johnsen, Helle Frost Andreassen, Lars Pedersen, Cecilia Ebba Clara Ellinor Lindnér, Lothar Wiese, Lene Surland Knudsen, Nikolaj Julian Skrøder Nytofte, Signe Ravn Havmøller, Maria Expósito, José Badillo, Ana Martínez, Elena Abad, Ana Chamorro, Ariadna Figuerola, Lourdes Mateu, Sergio España, Maria Constanza Lucero, José Ramón Santos, Gemma Lladós, Cristina Lopez, Lydia Carabias, Daniel Molina‐Morant, Cora Loste, Carmen Bracke, Adrián Siles, Eduardo Fernández‐Cruz, Marisa Di Natale, Sergiu Padure, Jimena Gomez, Cristina Ausín, Eva Cervilla, Héctor Balastegui, Carmen Rodríguez Sáinz, Paco Lopez, Javier Carbone, Mariam Escobar, Leire Balerdi, Almudena Legarda, Montserrat Roldán, Laura Letona, José Muñóz, Daniel Camprubí, José Ramón Arribas, Rocio Montejano Sánchez, Beatriz Díaz‐Pollán, Stefan Stewart, Irene Garcia, Alberto M Borobia, Marta Mora-Rillo, Vicente Estrada, Noemí Cabello, M.J. Nuñez-Orantos, Íñigo Sagastagoitia, J.R. Homen, Eva Orviz, Adrián Sánchez Montalvá, Juan Espinosa‐Pereiro, Pau Bosch‐Nicolau, Fernando Salvador, Joaquín Burgos, José Luís Morales‐Rull, Anna Maria Moreno Pena, Cristina Acosta, Cristina Solé-Felip, Juan P Horcajada, Elena Sendra, Silvia Castañeda, Inmaculada López-Montesinos, Joan Gómez‐Junyent, Carlota Gudiol Gonzáles, Guilermo Cuervo, Miquel Pujol, Jordi Carratalà, Sebastián Videla, Huldrych F. Günthard, Dominique L Braun, Emily West, Khadija M’Rabeth-Bensalah, Mareile L. 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Bice, Katherine Ognenovska, Gesalit Cabrera, Ruth Flynn, Barnaby Edward Young, Po Ying Chia, Tau Hong Lee, Ray J Lin, David Chien Lye, Sean Wei Xiang Ong, Ser Hon Puah, Tsin Wen Yeo, Shiau Hui Diong, Juwinda Ongko, He Ping Yeo, Nnakelu Eriobu, Vivian Kwaghe, Habib Zaiyad, Godwin Idoko, Blessing Uche, Poongulali Selvamuthu, Nagalingeswaran Kumarasamy, Faith Ester Beulah, Narayan Govindarajan, Kowsalya Mariyappan, Marcelo Losso, Cecilia Abela, Renzo Moretto, Carlos G. Belloc, Jael Ludueña, Josefina Amar, Marcelo Losso, Javier Toibaro, Laura Moreno Macias, Lucia Fernandez, Pablo S. Frare, Sebastián Chaio, Valeria Pachioli, Stella M. Timpano, Marisa del Lujan Sanchez, Mariana de Paz Sierra, Vanina Stanek, Waldo Belloso, Flavia L. Cilenti, Ricardo Valentini, Martín E. Stryjewski, Nicolas Locatelli, Riera Maria C Soler, Clara Salgado, Inés Baeck, Castelnuovo Valentina Di, Stella M. Zarza, Fleur Hudson, Mahesh Parmar, Anna L Goodman, Jonathan Badrock, Adam Gregory, Katharine J. 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L. Leonard, Tkiinomuhisha Deus, Namasaba Babra, Paul Taire, Joseph Lutaakome, Evelyn Nabankema, Joseph Ogavu, Oscar Mugerwa, Ivan Okoth, Raymond Mwebaze, Timothy Mugabi, Anthony Makhoba, Phiona Arikiriza, Nabuuma Theresa, Hope Nakayima, Kisuule Frank, Patrícia Ramgi, Kássia Pereira, Anu Osinusi, Huyen Cao, Paul Klekotka, Karen Price, Ajay Nirula, Suzette Y. Osei, Craig Tipple, Angela Wills, Amanda Peppercorn, Helen Watson, Rajesh Gupta, Elizabeth Alexander, Erik Mogalian, Leo Lin, Xiao Ding, David M. Margolis, Yan Li, Jean‐Luc Girardet, Ji Ma, Zhi Hong, Quing Zhu, Seth Seegobin, M.R.J. Gibbs, Mickel Latchman, Katarzyna Hasior, Jérôme Bouquet, Jianxin Wei, Katie Streicher, Albert E. Schmelzer, Dennis Brooks, Jonny Butcher, Dimitar Tonev, Douglas Arbetter, Philippe Damstetter, Philippe Legenne, Michael T. Stumpp, Susana Gonçalves, Krishnan Ramanathan, Richa Chandra, Beth Baseler, Marc Teitelbaum, Adam Schechner, H. Preston Holley, Shirley Jankelevich, Amy Adams, Nancy Becker, Suzanne Dolney, Debbie Hissey, Shelly Simpson, Mi Ha Kim, Joy Beeler, Liam Harmon, Mabel Asomah, Yvonne Jato, April Stottlemyer, Olivia Tang, Sharon Vanderpuye, Lindsey Yeon, Molly Buehn, Vanessa Eccard-Koons, Sadie Frary, Leah MacDonald, Jennifer Cash, Lisa Hoopengardner, Jessica Linton, Marylu Schaffhauser, Michaela Nelson, Mary Spinelli-Nadzam, Calvin Proffitt, Christopher Lee, Theresa Engel, Laura Fontaine, CK Osborne, Matt Hohn, Michael Galcik, DeeDee Thompson, Stacey Kopka, Denise Shelley, Gregg Mendez, Shawn T. Brown, Sara Albert, Abby Balde, Michelle Baracz, Mona Bielica, Shere Billouin-Frazier, Jay Choudary, Mary Dixon, Carolyn Eyler, Leanne Frye, Jensen Gertz, Lisa Giebeig, Neelam Gulati, Liz Hankinson, Debi Hogarty, Lynda Huber, Gary Krauss, Eileen T. Lake, Meryan Manandhar, Erin R. Rudzinski, Jen Sandrus, Connie Suders, Ven Natarajan, Adam Rupert, Michael Baseler, Danielle Lynam, Tomozumi Imamichi, Sylvain Laverdure, Ashley L. McCormack, Sharada Paudel, Kyndal Cook, Kendra Haupt, Ayub Khan, Allison Hazen, Yunden Badralmaa, Kenneth E. Smith, Bhakti Patel, Amanda Kubernac, Robert Kubernac, Marie L. Hoover, Courtney Solomon, Marium Rashid, Joseph Murphy, Craig Brown, Nadine DuChateau, Sadie Ellis, Adam Flosi, Lisa Fox, Les Johnson, Rich Nelson, Jelena Stojanović, Amy Treagus, Christine Wenner, Richard Williams · 发表于：Clinical Infectious Diseases · 年份：2024 · DOI：10.1093/cid/ciad780 · 被引用次数：16 · 研究领域：COVID-19 Clinical Research Studies、SARS-CoV-2 and COVID-19 Research、SARS-CoV-2 detection and testing

BACKGROUND: Persistent mortality in adults hospitalized due to acute COVID-19 justifies pursuit of disease mechanisms and potential therapies. The aim was to evaluate which virus and host response factors were associated with mortality risk among participants in Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3) trials. METHODS: A secondary analysis of 2625 adults hospitalized for acute SARS-CoV-2 infection randomized to 1 of 5 antiviral products or matched placebo in 114 centers on 4 continents. Uniform, site-level collection of participant baseline clinical variables was performed. Research laboratories assayed baseline upper respiratory swabs for SARS-CoV-2 viral RNA and plasma for anti-SARS-CoV-2 antibodies, SARS-CoV-2 nucleocapsid antigen (viral Ag), and interleukin-6 (IL-6). Associations between factors and time to mortality by 90 days were assessed using univariate and multivariable Cox proportional hazards models. RESULTS: Viral Ag ≥4500 ng/L (vs <200 ng/L; adjusted hazard ratio [aHR], 2.07; 1.29-3.34), viral RNA (<35 000 copies/mL [aHR, 2.42; 1.09-5.34], ≥35 000 copies/mL [aHR, 2.84; 1.29-6.28], vs below detection), respiratory support (<4 L O2 [aHR, 1.84; 1.06-3.22]; ≥4 L O2 [aHR, 4.41; 2.63-7.39], or noninvasive ventilation/high-flow nasal cannula [aHR, 11.30; 6.46-19.75] vs no oxygen), renal impairment (aHR, 1.77; 1.29-2.42), and IL-6 >5.8 ng/L (aHR, 2.54 [1.74-3.70] vs ≤5.8 ng/L) were significantly associated with mortality risk in final adjusted analyses. ...