Incidence and warning signs for complications of human brucellosis: a multi-center observational study from China

作者：Qingnan Shi, Huijie Qin, Qiao‐Shan Lu, Shu Li, Zhongfa Tao, Meng-Guang Fan, Mu-Heta Aishan, Zengqiang Kou, Qiulan Chen, Wen-Wu Yin, Yanping Zhang · 发表于：Infectious Diseases of Poverty · 年份：2024 · DOI：10.1186/s40249-024-01186-4 · 被引用次数：26 · 研究领域：Brucella: diagnosis, epidemiology, treatment、Zoonotic diseases and public health、Burkholderia infections and melioidosis

BACKGROUND: Brucellosis is a severe zoonotic disease that is often overlooked, particularly in impoverished countries. Timely identification of focal complications in brucellosis is crucial for improving treatment outcomes. However, there is currently a lack of established indicators or biomarkers for diagnosing these complications. Therefore, this study aimed to investigate potential warning signs of focal complications in human brucellosis, with the goal of providing practical parameters for clinicians to aid in the diagnosis and management of patients. METHODS: A multi-center cross-sectional study was conducted in China from December 2019 to August 2021. The study aimed to investigate the clinical characteristics and complications of patients with brucellosis using a questionnaire survey and medical record system. The presence of warning signs for complications was assessed using univariate and multivariate logistic regression models. Receiver operating characteristic (ROC) curves and the area under the curve (AUC) were used for variable screening and model evaluation. RESULTS: A total of 880 participants diagnosed with human brucellosis were enrolled. The median age of the patients was 50 years [interquartile range (IQR): 41.5-58.0], and 54.8% had complications. The most common organ system affected by complications was the osteoarticular system (43.1%), with peripheral arthritis (30.0%), spondylitis (16.6%), paravertebral abscess (5.0%), and sacroiliitis (2.7%) being the...