Evaluation of therapeutic effect and prognostic value of 18F-FDG PET/CT in different treatment nodes of DLBCL patients

作者：Wenyu Zhao, Xiaodong Wu, Shuo Huang, Hui Wang, Hongliang Fu · 发表于：EJNMMI Research · 年份：2024 · DOI：10.1186/s13550-024-01074-w · 被引用次数：9 · 研究领域：Lymphoma Diagnosis and Treatment、Medical Imaging Techniques and Applications、CNS Lymphoma Diagnosis and Treatment

Abstract Background In the present study, we aimed to investigate the role of baseline (B), interim (I) and end-of-treatment (Eot) 18 F-FDG PET/CT in assessing the prognosis of diffuse large B cell lymphoma (DLBCL), so as to identify patients who need intensive treatment at an early stage. Methods A total of 127 DLBCL patients (62 men; 65 women; median age 62 years) were retrospectively analyzed in this study. Baseline ( n = 127), interim ( n = 127, after 3–4 cycles) and end-of-treatment ( n = 53, after 6–8 cycles) PET/CT images were re-evaluated; semi-quantitative parameters such as maximum standardized uptake value of lesion-to-liver ratio (SUVmax (LLR) ) and lesion-to-mediastinum ratio (SUVmax (LMR) ), total metabolic tumor volume (TMTV) and total metabolic tumor volume (TLG) were recorded. ΔTLG 1 was the change of interim relative to baseline TLG (I to B), ΔTLG 2 (Eot to B). ΔSUVmax and ΔTMTV were the same algorithm. The visual Deauville 5-point scale (D-5PS) has been adopted as the major criterion for PET evaluation. Visual analysis (VA) and semi-quantitative parameters were assessed for the ability to predict progression-free survival (PFS) and overall survival (OS) by using Kaplan–Meier method, cox regression and logistic regression analysis. When visual and semi-quantitative analysis are combined, the result is only positive if both are positive. Results At a median follow-up of 34 months, the median PFS and OS were 20 and 32 months. The survival curve analysis showed...