Association Between Number of Missing Teeth and Hyperlipidemia: The TCLSIH Cohort Study

作者：Feng Qiao, Hong Guo, Jing Zhang, Qing Zhang, Li Liu, Ge Meng, Hongmei Wu, Yeqing Gu, Kun Song, Changyi Li, Kaijun Niu · 发表于：Journal of Inflammation Research · 年份：2024 · DOI：10.2147/jir.s443940 · 被引用次数：5 · 研究领域：Forensic Anthropology and Bioarchaeology Studies、Oral microbiology and periodontitis research、Dental Health and Care Utilization

Background: To explore the association between the number of missing teeth and the prevalence of hyperlipidemia in a Chinese adult population. Methods: 13,932 adults were investigated in the TCLSIH cohort study. The number of missing teeth was determined at baseline through a self-reported questionnaire, and then classified into three categories: 0, 1– 2, and ≥ 3. We defined hyperlipidemia as total cholesterol (TC) ≥ 5.17 mmol/L or triglycerides (TG) ≥ 1.7 mmol/L or low-density lipoprotein (LDL) cholesterol ≥ 3.37 mmol/L or a self-report of physician-diagnosed hyperlipidemia during follow-up visits. Cox proportional-hazards regression models were employed to assess the relationship between the number of missing teeth and incident hyperlipidemia. Results: A total of 6756 first-incident cases of hyperlipidemia occurred during 42,048 person-years of follow-up (median follow-up, 4.2 years). After adjusted confounders, multivariable HRs and 95% CI for incident of hyperlipidemia across the categories of missing teeth were as follows: in male participants, 1.00 (reference), 1.10 (0.98, 1.22), and 1.03 (0.91, 1.16) ( P for trend = 0.30); in female participants, 1.00 (reference), 1.09 (0.99, 1.19), and 1.18 (1.04, 1.33) ( P for trend < 0.01). Conclusion: The number of missing teeth is associated with an increased risk of hyperlipidemia in female participants but not in male participants. Systemic chronic inflammation may potentially mediate this association. Keywords: tooth loss, dysl...