RNA Interference With Zilebesiran for Mild to Moderate Hypertension

作者：George L. Bakris, Manish Saxena, Anil Gupta, Fadi M. Chalhoub, Jong-Tae Lee, Daniel Stiglitz, Nune Makarova, Nitender Goyal, Weinong Guo, Dion Zappe, Akshay S. Desai, KARDIA-1 Study Group, George Carr, Christopher Case, Lauren Hubert Jaeger, Lisa Bruns, Ginger Stratman, Christy Kidwell, Suzin Cunningham, Nicholas Piccone, Mordecai Klein, Maria Acuna, Srishti Arora, Amanda Clark, Ezekiel Fink, Cesia Garcia, Astrid George, ELIZABETH S. GRAY, Caroline Mahaffey, Maria McElheney, Elizabeth Reyes Ortíz, Sunny Saumya, Adele Wallace, Jenelle Watts, Daisy Zambrana, Douglas Scott Denham, Erica Rivera, Ayoade Avworo, Parke Hedges, Corri Fancher, Rafik Abadier, Lisa Braud, Laura Cenatiempo, Amanda Elwood, Linda Gray, Peter Gray, Kimberly Griffin, Hasibul Khan, Nadeen Kongquee, Susan LaTorraca, Tiffany Liles, J. M. Livingston, Marc Lozano, Amy Lupton, Tiffany Lyles, Deana Mardini, Susan M. Moss, K. Packer, Aakash Patel, Tina Russ, Brianna Scinicariello, Shannon Trull, Blair Warren, Fadi M. Chalhoub, Susan Angel, Sujeeta Dhakhwa, Ivy Gabon, Leticia Goodwin, Nandita Joshi Jones, Mark Joyce, Niketa Kamble, Brooke McFall, Rose Githiiyu, Leticia Robinson, Lauren A. Tomlinson, Emir Hadziavdic, Stephany Vega, James H. Greenwald, Jessica Achan, L Poyatos Ruiz, Mehwish Buksh, Omkar Chauhan, Elisee Derisseau, Faith Ferguson, Monika Grabowski, Larisa Gumerova, Miriam Hernandez, Kenna Martin, Krina K. Patel, Dibnain Nanda, José Garcı́a Pérez, Corey Ribeca, Elijah Rueda, Ana Sordi Guth, Nader Zaki, Ebony Green, Nina Mondoc, Robert J. Buynak, Stephanie Andree, Martha Brazinsky, Lisa Fuller, Nikki Green, Hannade Ibrahim, Marilyn Idowu, Miranda Lee, Erica Lewis, Goldie Luna, Rachel McNeal, Alicia Owens, Consuelita Perez, Taryn Petty, Megan Smith, Patricia Volom, Angela Webb, Destiny Williams, Mark Yarosz, Nashwa Gabra, Nabil S. Andrawis, Amy Aziz, Magda Hanna, Josefina Manalo, Victoria Helow, William Davila, Sydney Crisp, Yvonne L. Douglas, Jenna Everett, Sarah Anne Graham, Ellen Heard, Michelle Mackie, Suman Mayer, Lisa Dorothy Moore, Stephanie Resurreccion, Jennifer Sidey, Michael C. Stephens, Mary Strickland, Dawn Van Camp, Stephanie Wilder, Anne Møller Witt, Jolenne Wolfer, L. Groben, Lindsey Aeschliman, Emily Audlehelm, Casey Fitz, Judi Greene, Emily Hippen, Michelle Smith Johnson, Allan P. Latcham, Shekela Leggett, K. Link, James E. J. Lovell, Kourtney Marlow, Cynthia Marske, Kelsey N. Maxwell, Charlotte Newsom-Henderson, Darcie Oelberg, Kathleen Ollinger, Rebecca Risius, Kylea Ryther, Alyssa Waddell, Tyler Zellerman, Martin Albornoz Santofimio, Stephen Plantholt, Morgan Beatty, Heather Taylor Blubaugh, Tina Bootz, Jeffrey A. Cole, Jasmine Conners, Vicki J. Coombs, Chloe Goddard, Carlos Ince, Gail Kiddy, Barbara Klimuszka, Frederick A. Kuhn, David C. Lowry, Patricia Previll, Stephanie Rioux, Jasmine Scott, B. A. Shepherd, Amy Urffer, Sarah L. Smiley, Gregg H. Lucksinger, Allison Alvord, J.D. Anderson, Courtney M. Block, Ashley S. M. Chan, John Delgado, Kambrea Frost, Levi Gadbois, Danuel Hamlin, Sarah Johnson, Vivianna Juncal, Kary Kelly, Emily Kelly, Lilly Kelly, Avery Kerwin, Audrey Kuehl, Jaleh Ostovar, Ryan Rackley, George J. M. Rocha, L.B. Sandberg, Sarah Sheghewi, Tiffany M. Smith, Ben Taucher, Cecilia A. Vasquez, Francisca Villa Rodriguez, Jay Weisbart, Veronica Wescom, Keenan Williams, Jeffrey Scott Overcash, Angela Anorve, Hunter Asmann, Gordon Bovee, Laura Castillo, Hanh Thi Chu, Jordan Coslet, Allison Davis, Mary Dinan, Amanda Dubbula, Jacob Esparza, ANN C. FOSTER, Andrea Arnaiz García, Jessica Gonzales, Lizette Gonzalez, Pat Kappen, Allison Kornblatt, Brandon Lauderdale, Kia Lee, Sylvia Lindholm, Ashliegh Lindsay, Luis Llanos Gomez, Adrienna Marquez, Catherine Meza, Shandel Odom, Makenna Orel, Shanna Paselio, Samuel Penziner, Helen Pu, Kimberly Quillin, César E. Ramírez, Roxanna Ramirez, Mônica Santos Salgado, Marcy Shores, Raquel Taitingfong, Jennifer Tande, Van Tuiletufuga, Katrina Tyler, Linda Vega, Karla Zepeda, Corey L. Anderson, Nikki Carhill, Benjamin Clark, Lisa Dean, Naomi Devine, Sophia DiPeri, Gladys Espinal, Ronald E. Hawkins, Gabriela Irra, Angela Ledezma, Georgina Lopez-Wood, Micaela Luna, Wael Yassin Mansour, Tasha Marriott, Ashley Perez, James M. Ramsey, W. Jay Reedy, Hannah Spinks, Cecilia Tanori, David Tatelbaum, Rudy Vasquez, Kim Vasquez, Jori Vigil, Isabel Worthen, Devin Yu, Jessica N. Zuniga, Patrick Dennis, Lauren Alvarado, Armand Cox, Victoria Cullaro, John Dunbar, Katherine Giorlando, London Hannan, Tyler Hastings, Geoff Hoskins, Emily Krambeck, Juliana Laurent, Olga Michelle Martinez, Reggie Mister, Autumn Moss, Margaret Muli, Nicolette Quinn, Brittany Reed, Adam Robinson, Casey Saavedra, Caitlin Simon, Derek Richard SMITH, Dylan Touchet, Annie Wright, Miguel Trevino, Benjamin DeVries, Sara Allison-Hicks, Timothy D. Light, Wendy Rubach, Kimberly Mai, Tracey Osborn, Lori Sheets, Dusty Carver, Alan J. Reichman, Djamchid Lotfi, Nelson Berrios, Sangeetha Vulichi, Tulashi Naguleswaran, Yvonne Subhan, Mónica Ríos, Diana Baron, Abdul Khowaja, Siddharth Nair, Michaël Vicente, Luvia Lizette Gonzalez Gomez, Uriel Salvador Acevedo Gómez, Janak Lamichhane, Efe Ekomoda, Akhila Nair, Shana Maldonado, Mobina Naqvi, Fahim Dayani, Sontoshi Patro, LubnaGazal Golandaz, Amin Jaka, Santiago Rios, Maushami Gurung, Pratik Gongloor, David Coreas, Tarık Demir, Zehra Celik, Lora McGill, Lisa S. Usdan, Valerie K. Arnold, Keerthi Heckle, Carolyn Scatamacchia, Codi M. Anthony, Carol Marsh, Jernell Fair, Anekeya Stewart, R. Hamlet, Robyn Presley, Charles Granberry, Melissa Flowers, Cathy Houpt, Debra O’Brien, Kelsey M. Evans, Mary L.K. Williams, Julia Sinatra, Irene Powell, Tavia Flagg, LaKeshia Pipkin, Vanessa C. Wheeler, Erin Wells, Brandi Gruber, Amber Jones, Monica Toor, Kelly Iskiwitz, Mia Boyd, Sharneiseca Epps, Frank Cole, Charlotte Grayson-Mathis, Maci Web, Catrina Turner, Krystal Reese, Dana Robinson, Atira Goodwin, Kyle Parker, Chantelle Ward, Amber Solomon, Taylor B. Lawson, Marquita Pledger, Amanda Lane Peterson, Monique Carignan, David Oguoma-Richards, Stacy A Jones, Kiara McFarland-Head, Brittany Bundeff, Stephanie Wojtowicz, Cynthia Holland, Taylor Sanders, Simon Lee, Caitlin Lawrence, Brittany Bolton, Kandice Lemoine, Kasey Harris, Hilary Kingsley, Danielle Bryant, Korie Clawson, Colleen K Murphy, Dale Crawford Allison, Gregory A. Newman, Dedra Preece, Pamela Zook, Taylor Roznos, Sharla Russell, Richard Aristeo Rodriguez, Angela Roy, Stacey Layle, Purvi Mehra, Samantha Bowen, Daniel Johnson, Natalie Guillen, Sofia Leone, Guinevere McCormick, Laurel Hermann, Lerner Sarno, Taher Abellatif, Monica Cleghorn, Aya Elansary, Athalyah Israel, Michelle Leeward, Claudia Parra-Ruiz, Sydney Harris, Prianka Patel, Megan Cawley, Myrna Castro, Tatyana Miroshnikova, Michael E. Dever, Jorge Venereo, Henry Paez, Andres Isla, Yailin Martin, Ana María Fernández, Isabel A. Pérez Hernández, Andrew Isla Lavoy, Nancy Ríos, Armando E. del Río Hernández, Michael Denenberg, Treacy McTier, Caroline Reynolds, Lacie Thomas, Connie Eubanks, Tori Oliver, Michael Jacobs, Vincent Mirkil, Kathleen Menasche, Michael S. Yee, Bonny Alvarado Vasquez, Candice Garcia, Laura Elio, Allan Arenas, Clarissa Buena, Cristina Martínez García, Michael D. Cannon, Erin Novotny, Michelle Oliver, Amanda Cannon, Mark Gatdula, Cyn Gillenwater, Adam Rafi, Wissam Derian, Miranda Ramsey, Evan Culbreth, Catherine Fessler, Kelly Sorrill, Monica Mauri, Jeffrey Bruce Rosen, Olga Lucía Acosta, Walter Brauchle, Dadllany Castaneda, M. Rodriguez Castells, Daniela Castro, M. Laplace, Magdala Flerisme, Rocío García-Jiménez, Julio Goméz, Michael Hidalgo, Gabriela Jiménez, Miguel Legon, V Di Lella, Kimanys Lemus, Sheilla Rico-Aramillo, Maria Alma Rodriguez, Yelida Rodriguez, Latisha Salazar, Carlos Santana, Nelly Tercero, Earl E. Martin, Marìa Fernanda Troncoso Acevedo, Amy Anderson, Talha Baig, R. M. L. BAKER, Reemsha Basrai, Nora Cabrera, C. Patrick Caroll, Shanika Chatmon, Sukhvinder Cheema, Anum Chowdhry, Nicole Cordero, Carolina Deandres, Mounika Deshpande, Ambily Dileep, Kimberly Dolfi, Lara Eng, Niccirria Fountain, Ramani Gali, Adrienne Hernandez, Arsani Iskandar, Riaz Anwar Khan, Adrianna Knight, Soni Kundapati, Irma Lobo, Zahra Lokhandwala, Zara Lokhandwala, Faryal Mahmood, Rifa Marediya, Earl F Martin, Mirella Melendez, Asfand Moosa, Alefiyah Motiwala, Shamnun Muhebb, Monica Murray, Muneeb Rehman, Ariel Rivera, Ashay A. Shah, Sara Solórzano, L. L. Somani, Loreta Soneira, Amy Starr, Danielle Thompson, Andrea D. Torres, Elizabeth U. Tran, Mohammad Ali Ullah, A. Valentine, Laura Vaquerano, Amanda Yake, Yousra Yousif, Ashley Zaldivar, William Byars, Hillary Brown, Anne Claire Gaskin, Caitlynn Clayton, Christopher R. Davis, Sydney Dillon, Belinda Driggers, Anfernee Ferrell, D Green, Lisa Hunt, Cathleen Jeffers, C. Tyler Kirkland, Lina Lopez, Ronald K. Mayfield, Carole Mercer, K F Parsons, Sharon F. Patton, Kayla Puck, Lina Restrepo, Tanya Sheppard, Gina Teachman, Jessica Velez, Amanda Whitehead, Mahendra Jain, Gloria Asanji, Jennifer Walz Garrett, Katie Gill, D. Micah Hester, Bela Jain, Yvette Mitchell, Teresa M. Becker, Cecilia McKeown-Biagas, Veronica G. Fragoso, Lisa A. Holloway, Tracy Kowalski, Shakira Barr, Bonnie Colville, Chen-Ho Yang, Danitra Glasper, Allan Phuah, Vicki Miller, Sheila E. Schmidt, Ashraf Jafri, Waheeda Sureshbabu, Leena Mir, Stuti Sharma, Saja Asaad, Muhammad Hasnain, Tru Ngo, Devi Hari, Ikenna Oheri, Asma Patwary, Mahmoud Mohamed, Priscilla Hernández, Jonatan Gioia, Abdeali Dalal, Pauline Ngban, Sandra J. Smith, Bernardo Martinez Leal, Akram Assaf, Alondra Martinez, Khola Waheed Khan, Jacqueline Castello, Mariya Potapenko, Zurzar Wahaj, Faris Elmachtoub, Amna Akhtar, Muhammad Areeb Siddiqui, Maira Jamal, Mohammad Rizvi, Karina Sainz, Sarah Lucky-Dania, Stacy Villarreal, William G. Fernandez, Shamarrian Hampton, Jerry Bellamy, Lonisha Brown, Evan Doran, Eduardo Manzanares, James Caldwell Palmer, Aaron P. Sanders, Faraya Bokhari, Omowunmi Fenuyi, Clarissia Greer, Hansol Jang, Andrea Juanillo, Crystal Reese, Dheeraj Narla, I.E. Okoko, Cara Woodham, Rose Eaton, Shariqa Khawaja, Tehreem Mushtag, Asifa Nisar Bhutto, Sara Solorsano, Sajeel Ahmed, Rabia Shamim, Norma Gonzalez, Felicia Ardoin, Joshua A. Moore, Nina Nuncio, Eric Ray, Kara Sikes, Imani Troutman, Natasha West, Q. C. Wilson, Nikisha Young, Misbah Baloch, Najmuddin Karimjee, Kristy Carroll, Sakina Broachwala, Natalee Calais, Jessica Laabs, Karen Marler, Samana Rizvi, Amar Syed, Narjis Syed, Zamir Rizvi, Zohair Hariwala, Patty Gloyd, Abid Rizvi, Benjamin Marcum, Joshua Carswell, Cortney Fanning, Lesslie Bull, Peter Corta, Holly James, David Martı́nez, Robin Scurlark, Stephanie Elliott, Sydney Beck, Cayla Beck, Sarah Glover, Jasmine Bonson, Tanisha Patel, G. Douglas Matthew, Kyla Davidoff, Jim Vesely, Cyrus Horton, Rebecca Barbour, Isabel Pereira, Gina Rivero, Denise Alston, Paulina Miller, Frances Downing, Nelia Sanchez Crespo, Howard Schwartz, Surisaday Mederos, Janet Sentil Tamayo, Craig A. Shapiro, Orbein Mallet, Karenda Plotka, Carlos Valladares, Karenda Palmer, Dayana Deltejo, Katherine García, Marilein Camacho, Yarixa Chanza, J. Morera, Claudette P. Davis, Karlene Dawson, Vivian Rosales, Dunia Torres, Maria Pinero, Catherine Cruz, Beatriz Rivera, Patricia Balebona, Andrea Basurco, Jenny Montoya, Mikael Yaniz, Pedro Petit Phar, Christy Filgueiras, May Fernandez, Latauri Skrine, Aaliarys Alcantara, Isnier Parodis, Jessica Parodis, Jailene Jara, Joslandey Alouption, Malvin Yan, Jesse Padilla, Carolina Uribe Cruz, Bianca Bran, Vanessa Giavarotti Taboza Flores, Leandro Perez, Arthur J. Labovitz, Tracey Roth, Julian Javier, Lorenzo Jiménez, Carmen Ojeda, María Elisa Quinteros Cáceres, Caren Misir, Kyle Rudd, Juan Ramos, Wasim Deeb, Mohannad B. Bisharat, Amy Dennis-Saltz, DAVID R. SUTTON, James Fergall Magee, Majdi Ashchi, Rebecca F. Goldfaden, Mae Sheikh‐Ali, Stacey Kelly, Elias Nicolas Saikali, Gloria Rodel Ramirez, Debbie Domingo, William Hodge, Adrienne Greenewalt, Lauren Stamschror, Kaitlyn Preston, Leann Petschonek, K. Graf, Lynsey Sutton, Meghan Edson, Madison Charron, Mika Taylor, Emily Knisely, Ashwini Gore, Thomas R. Jones, Barry Johns, Jennifer Sheldon, Kayla Merritt, Lisa Hichkad, Leah Barbee, Amanda Riley, Lindsay M. Alexander, Lilly Dasher, Elio Argimiro Torres Lopez, Rafael Baez Bonilla, Anibal Loza, Dunia Hernandez, Y. Martínez Perez, Alejandro Perez, Yalily Perez, Denisse Medina, Emilio Mantero, Ramses Vega, Noel Pedraza, Damian Sosa, Lys Robles, Yennifer Machado, Yoandra Sosa, David Guzman, Maricor Grio, Juan P. Frías, Sharon M. Kelly, Mark T. Leibowitz, J. Craig Nelson, Cheryll Handy, A. Greenberg, Norma Vega, Angelica Francisco, Coralia Soto, Sinthia Arcadia, Eulalia Francisco, Nicol Escareno, Nelly Ayala, Jennifer Muniz, Jose Espino, Daniel Vargas, Rosie Jimenez, Stéphanie Lopez, Iliana Gallaga, Genesis  Heredia, Elizabeth Barranco Santana, Rafael Mendoza-Rodriguez, Sara Cancel Santana, Alejandra Román, Irmaris Arroyo Torres, Velma Franceschini, Brenda D. Garcia, Nancy Jimenez, Michele Irizarry Ortiz, Armando Torres Antommattei, Angel Comulada-Rivera, Alejandro Perera Pintado, Sonia Ortiz, Adamaris Rodriguez, Rosa Mojica Ramirez, Anthony Olofintuyi, Ricardo Alvarez, Jay Pitts, Jackelyn Samraj, Alma Vasbinder, Amaya Averett, Thomas M. Kane, Harlicia Farley, Thomas Kendall, Richard Kemmerlin, Jackie Saunders, Yolanda Livingston, Barry McLean, Maureen Mayer, Valerie Goodwin, Evelyne Ngugi, Prateek Mishra, Hannah Elizabeth Carter, Lorie Szymela, Muhammad Ali Imran, Saiaf Abdallah, Nadia Clarke, Sylvania Hernandez Latog, Broderick Moore, Miguel López, Maureen Tagsip, Prakash Nepali, Nivi Kumaran, Greta Jacinto, Catherine Magsino, Freddie Batalla, Feroza Imran, Richard Murdoch Montgomery, Stephanie Riggs, Shavonna Haamid, Catherine Whitt, William J. Hopper, Dominique R. Smith, Julia Kordsmeier, Courtney Sherron, Miyah Plummer, Sherisse Jimenez, Airelle Newkirk, Laura Murray, Haley M. Scott, Rebecca Whitney, Monica J. Castro, Michelle Rhames, Gregorio Cortes-Maisonet, Luis Miranda Martinez, Myriam Zaydee Allende-Vigo, Karina Vila, Michelle Santiago Rivera, V. M. Yunker, Bryan Rivera, Alex C. Rodriguez, Carla Lázaro Rivera, Genesis Reyes Blanco, Keven Batista Colon, Mariely Cruz, Chinedu Nweke, Norah Okafor, Angela Nweke, Daisy Chaves-Montoya, Heather Patrick, Stephanie Alvarez, Eunice Momeh, Cyriacus Anaele, Katherine McArthur, Peter Longonje, D R Husbands, Iasia Williams, Christine Dillingham, Gloria Sanchez Sayyah, Laura Carey, Clarissa Brock, Rubaba Hussain, Khadiza Sultana, Omar Taufeeq Mohammad, Jennifer López, Valeria Bittencourt, Sneha Prasad, Nafsun Akther, Timothy Richard Smith, Sheri Rocco, Donna Straatmann, Jill Stoneman, Elizabeth Maryas, J Gravier, Walter Faggett, Andrés Serrano Jiménez, Maria Maya Alvarez, Wendy Evora, Alcira Herrera, Lorena Leonardi, Adam D. Karns, Edith Sisneros, Sarom Hong, Iurii Stepanovich Rudyk, O Medentseva, Maryna Alexeeva, Nataliya Strakhova, Tetyana Lozyk, Denys Babichev, Kostiantyn O. Yushko, Vira Tseluyko, Andriy Zhadan, O. O. Butko, O. Ya. Mishchenko, Olha Ya. Radchenko, Oleksandr Karpenko, Polina Klimko, Anna Berezhniak, Liudmyla Todoriuk, S Bezuglova, Liubov Mitskevych, Світлана Кізім, Inna Nevolina, О. Е. Гальченко, Oleksii Korzh, Olena Pankova, Yana Fylenko, Valeriia Ziabchenko, Sergiy Krasnokutskiy, Artem Liashok, Oleksandra Donets, Anna Mishustina, Liliya Khrustalyova, Dmytro Donets, Yuliia Rybachok, Vyacheslav Senchylo, Iryna Lyakhova, Olena Takhaieva, А.О. Шкрьоба, Diana Shchypak, Nadiya Tryshchuk, Olga Pieshkova, Олена Карая, Anna Yakovleva, Olha Horoshko, Tetiana Lohdanidi, N Belei, Inga Kuzmenko, Tetiana Demchuk, S. V. Cherniuk, A. S. Kozliuk, Volodymyr Kovalenko, Valerii Adarichev, Vakaliuk Ip, Nataliia B. Tymochko, Volodymyra Sovtus, Nadiia Haliuk, Daniel Gaudet, F. Côté, Jean-Philippe Milot, Nathalie Roy, A. Larouche, J Piche, Laurie-Anne Charest, Josiane Dufour, Joannie Pageau, Noémie Audet-Verreault, Lyne Côté, Melissa Gagnon, Véronique Côté, Denise Morin, Jessica Fortin-Mimeault, Marc-Olivier Brassard, Hélène M. Gagné, Sophie Rousseau, Ying Tung Sia, Ezéquiel Guzzetti, Ramon Gisbert, Mariana Carvalho Dias, Mariana de Oliveira, Claudia Côté, Izabel Rodrigues, Johanne Blanchard, Laurence Labbé, Sabrina Dumoulin Lemay, Kathleen M. Beauchemin, Roxanne Turcotte, Annabelle Beaudoin, Chansamone Saliphod, Chantal Lamontagne, Josiane Trudel, Carolyne Beaudoin, Josée Blanchard, Annie Larouche, Cecile Robinaud, Valérie Paré, Alexandre Bergeron, Maude Bilodeau, Ethel Bellavance, Eve Betit, Karine Fortier, Josee Racine, Dinah Perras, Elyse Boulanger, Christelle Beauchesne, Sarah Lehoux, Vickie Turgeon, Rachele Cote, Marie-Eve Tardif, Naresh Aggarwal, Puja Aggarwal, Bharti K. Patel, Gurdeep Dhaliwal, Preeti Aggarwal, Guy Tellier, Gilbert Gagne, Luc Laperrière, Jennifer Shalala, Janelle Danchuk, Catherine M. Barrette, L Lauzon, Natalie Langille, Sarah Gagné, J. Lupien, Raphael Brochu, Sophie Coallier, Catherine Vaillancourt, Pierre Lachance, Diane Carbonneau, Hélène Thibault, Luc Bouchard, Andreanne St-Cyr, Johanne Rioux, Laureanne Quenneville, Constance Gagnon, Theana Nony, Pascale Laberge, Annabelle Corbin, Isabelle Patry, Sophie Savage, Melanie S. MacNeil, Andrea Murdock, J. C. Inglis, Katelyn Libbus, Kathryn Smith, Deseray Johnson, Linda Walters-Findlay, Laura K. Harris, Taylor A. Hutchison, Autumn Rafuse, Julie Thorsen, Greg MacDonald, Ronald Akhras, Richard Assef, Elise Irani, Rania Khayat, Scott Guidolin, Anil Gupta, David Anthony Price, Amisha Gandhi, Ajay Chhabra, Bhavya Gandhi, Shrey Acharya, Maheshwari Panchal, Bindu Kansal, G. HOWARD BAILEY, Paula Harvalik, Kerri Demchuk, Manish Saxena, David Collier, Colvell David, Benildo Jr Quiros, Mital Patel, Armida Balawon, Francis Galera, Ania Michalska, Brian Piniera, Rahat Uddin, Joanna Abbott, Karen Faulkner, Tamer Yousef, Kyle Love, Ariella Zagdanski, Susan Slaney, Michelle A. Anderson, Aimee Leath, Cheryl E. Dunlop, Elizabeth Hardy, Shannon C. Wall, Osman El‐Koubani, Tracy Kelt, Billy-Jean Connolly, Cheryl Marmion, Maheswari Alapati, Louise Simmons, Caroline Colquhoun, Darren Clyde, Adrian Mooty, Nicole Mullen, Marianne Viljoen, Lucy Trevor, Carol H. Pretswell, Catherine E. Austin, Chigomezgo Munthali, Imrozia Munsoor, Madhu Venkate Gowda, Pembe Ozunlu, Peter Keighley, Alison Jones, Annette A. James, Joanne Pollitt, Wendy Littlewood, Lena Al-Sheikhly, David J. Lee, Denise Nistor, Elaine Roberts, Gayle Mawdsley, Kamila Sobolewska, Katrina Hannis, Klaudia Wojtkiewicz, Lauren Stopford, Lindsay Halliwell, Veronica Mort, Victoria McGrath, Harry Osborne, Alison E. Merrick, Cathrine Basikolo, Inge Ghysels, Laura R. Fenlon, Lucy Beech, Olga Lusquinos Munoz, Sarah Bilton, Lyne Goddard, Tracey Gillon, Stacy Taylor, Brianne Tyson, Victoria Connor, Hannah Felber, Angela Fallows, Jacqueline Clowes, Shirley Cheung · 发表于：JAMA · 年份：2024 · DOI：10.1001/jama.2024.0728 · 被引用次数：130 · 研究领域：Renin-Angiotensin System Studies、Blood Pressure and Hypertension Studies、Protein Hydrolysis and Bioactive Peptides

Importance: Angiotensinogen is the most upstream precursor of the renin-angiotensin-aldosterone system, a key pathway in blood pressure (BP) regulation. Zilebesiran, an investigational RNA interference therapeutic, targets hepatic angiotensinogen synthesis. Objective: To evaluate antihypertensive efficacy and safety of different zilebesiran dosing regimens. Design, Setting, and Participants: This phase 2, randomized, double-blind, dose-ranging study of zilebesiran vs placebo was performed at 78 sites across 4 countries. Screening initiation occurred in July 2021 and the last patient visit of the 6-month study occurred in June 2023. Adults with mild to moderate hypertension, defined as daytime mean ambulatory systolic BP (SBP) of 135 to 160 mm Hg following antihypertensive washout, were randomized. Interventions: Randomization to 1 of 4 subcutaneous zilebesiran regimens (150, 300, or 600 mg once every 6 months or 300 mg once every 3 months) or placebo (once every 3 months) for 6 months. Main Outcomes and Measures: The primary end point was between-group difference in least-squares mean (LSM) change from baseline to month 3 in 24-hour mean ambulatory SBP. Results: Of 394 randomized patients, 377 (302 receiving zilebesiran and 75 receiving placebo) comprised the full analysis set (93 Black patients [24.7%]; 167 [44.3%] women; mean [SD] age, 57 [11] years). At 3 months, 24-hour mean ambulatory SBP changes from baseline were -7.3 mm Hg (95% CI, -10.3 to -4.4) with zilebesiran, 150...