Controllable Double Difluoromethylene Insertions into S−Cu Bonds: (Arylthio)tetrafluoroethylation of Aryl Iodides with TMSCF 2 Br

作者：Shitao Pan, Qiqiang Xie, Xiu Wang, Rumin Huang, Yuhao Lu, Chuanfa Ni, Jinbo Hu · 发表于：Angewandte Chemie International Edition · 年份：2024 · DOI：10.1002/anie.202400839 · 被引用次数：10 · 研究领域：Fluorine in Organic Chemistry、Inorganic Fluorides and Related Compounds

Abstract A new method of constructing “ArSCF 2 CF 2 Cu” from ArSCu and TMSCF 2 Br (TMS=trimethylsilyl) has been developed. The cross‐coupling reactions of the obtained “ArSCF 2 CF 2 Cu” with diverse aryl iodides (Ar′I) provide an efficient access to Ar′CF 2 CF 2 SAr. Mechanistic studies demonstrate that the “ArSCF 2 CF 2 Cu” species were generated through controllable double difluoromethylene insertions into ArS−Cu bonds rather than the 1,2‐addition of ArSCu to tetrafluoroethylene.