Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data

作者：Xin Wang, You Li, Ting Shi, Louis Bont, Helen Y. Chu, Heather J. Zar, Bhanu Wahi-Singh, Yiming Ma, Bingbing Cong, Emma Sharland, Richard D Riley, Jikui Deng, J. Figueras Aloy, Terho Heikkinen, Marcus Herbert Jones, Johannes G. Liese, Joško Markić, Asunción Mejías, Marta C. Nunes, Bernhard Resch, Ashish Satav, Kee Thai Yeo, Eric A. F. Simões, Harish Nair, Eurico Arruda, Vicky L. Baillie, Debora Chong, Rowena Crow, Nelson Augusto Rosário Filho, Matt Laubscher, Shabir A. Madhi, Dina Mrčela, Octavio Ramilo, Damir Roje, Renato T. Stein, Chee Fu Yung · 发表于：The Lancet · 年份：2024 · DOI：10.1016/s0140-6736(24)00138-7 · 被引用次数：188 · 研究领域：Respiratory viral infections research、COVID-19 Impact on Reproduction、Neonatal Respiratory Health Research

BACKGROUND: Infants and young children born prematurely are at high risk of severe acute lower respiratory infection (ALRI) caused by respiratory syncytial virus (RSV). In this study, we aimed to assess the global disease burden of and risk factors for RSV-associated ALRI in infants and young children born before 37 weeks of gestation. METHODS: We conducted a systematic review and meta-analysis of aggregated data from studies published between Jan 1, 1995, and Dec 31, 2021, identified from MEDLINE, Embase, and Global Health, and individual participant data shared by the Respiratory Virus Global Epidemiology Network on respiratory infectious diseases. We estimated RSV-associated ALRI incidence in community, hospital admission, in-hospital mortality, and overall mortality among children younger than 2 years born prematurely. We conducted two-stage random-effects meta-regression analyses accounting for chronological age groups, gestational age bands (early preterm, <32 weeks gestational age [wGA], and late preterm, 32 to <37 wGA), and changes over 5-year intervals from 2000 to 2019. Using individual participant data, we assessed perinatal, sociodemographic, and household factors, and underlying medical conditions for RSV-associated ALRI incidence, hospital admission, and three severity outcome groups (longer hospital stay [>4 days], use of supplemental oxygen and mechanical ventilation, or intensive care unit admission) by estimating pooled odds ratios (ORs) through a two-stage ...