Multi-functional composite dressings with sustained release of MSC-SLP and anti-adhesion property for accelerating wound healing

作者：Wu Duan, Haipeng Wang, Ziran Wang, Zhongjing Ren, Xinxin Li, Falian He, Shaomin Li, Yingchun Guan, Fuqiang Liu, Li Chen, Peng Yan, Xinguo Hou · 发表于：Materials Today Bio · 年份：2024 · DOI：10.1016/j.mtbio.2024.100979 · 被引用次数：14 · 研究领域：Wound Healing and Treatments、Electrospun Nanofibers in Biomedical Applications、Surgical Sutures and Adhesives

Exudate management is of significant clinical value for the treatment of acute wound. Various wound dressings have been developed to restore the function of injured tissues and promote wound healing, but proper exploiting the healing factors inside exudate and achieving anti-adhesion wound care remains a challenge. Herein, we present a novel multi-functional composite dressing (MCD) by coupling supernatant lyophilized powder of mesenchymal stem cells (MSC-SLP) with a sandwich-structured wound dressing (SWD). The developed MCDs demonstrated unique unidirectional drainage capability, stable anti-adhesion characteristics, and improved wound healing performance. The designed SWD with both superhydrophobic inner surface and liquid-absorption ability of mid layer enables the dressings exhibit desired anti-adhesion property to neoformative granulation tissues, favorable shielding effect to exogenous bacteria, as well as appropriate exudate-retaining capability and unidirectional exudate-absorption property. The introduction of MSC-SLP in SWD was demonstrated to further improve wound healing quality. Compared to medical gauze, the synergic effect of SWD and MSC-SLP significantly accelerates wound healing rate by over 30%, avoids tissue avulsion when changing dressings, and produces a flat-smooth closure surface. More importantly, the wound treated with MCDs presents more skin accessory organs and blood vessels in regenerated tissues than other groups. In vivo/vitro biocompatibility e...