Effect of Tai Chi vs Aerobic Exercise on Blood Pressure in Patients With Prehypertension

作者：Xinye Li, Peifen Chang, Min Wu, Yuchen Jiang, Yonghong Gao, Hengwen Chen, Liyuan Tao, Dawei Wei, Xiaochen Yang, Xingjiang Xiong, Yan Yang, Xiandu Pan, Ran Zhao, Fan Yang, Jiahao Sun, Shengjie Yang, Li Tian, Xiaofang He, Eryu Wang, Yiyuan Yang, Yanwei Xing · 发表于：JAMA Network Open · 年份：2024 · DOI：10.1001/jamanetworkopen.2023.54937 · 被引用次数：46 · 研究领域：Balance, Gait, and Falls Prevention、Cardiovascular and exercise physiology、Exercise and Physiological Responses

Importance: Prehypertension increases the risk of developing hypertension and other cardiovascular diseases. Early and effective intervention for patients with prehypertension is highly important. Objective: To assess the efficacy of Tai Chi vs aerobic exercise in patients with prehypertension. Design, Setting, and Participants: This prospective, single-blinded randomized clinical trial was conducted between July 25, 2019, and January 24, 2022, at 2 tertiary public hospitals in China. Participants included 342 adults aged 18 to 65 years with prehypertension, defined as systolic blood pressure (SBP) of 120 to 139 mm Hg and/or diastolic BP (DBP) of 80 to 89 mm Hg. Interventions: Participants were randomized in a 1:1 ratio to a Tai Chi group (n = 173) or an aerobic exercise group (n = 169). Both groups performed four 60-minute supervised sessions per week for 12 months. Main Outcomes and Measures: The primary outcome was SBP at 12 months obtained in the office setting. Secondary outcomes included SBP at 6 months and DBP at 6 and 12 months obtained in the office setting and 24-hour ambulatory BP at 12 months. Results: Of the 1189 patients screened, 342 (mean [SD] age, 49.3 [11.9] years; 166 men [48.5%] and 176 women [51.5%]) were randomized to 1 of 2 intervention groups: 173 to Tai Chi and 169 to aerobic exercise. At 12 months, the change in office SBP was significantly different between groups by -2.40 (95% CI, -4.39 to -0.41) mm Hg (P = .02), with a mean (SD) change of -7.01 (1...