Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials

作者：Ilias Ι. Siempos, André C. Kalil, Drifa Belhadi, Viviane Cordeiro Veiga, Alexandre Biasi Cavalcanti, Westyn Branch‐Elliman, Eleni Papoutsi, Konstantinos Gkirgkiris, Nikoleta A. Xixi, Αναστασία Κοτανίδου, Olivier Hermine, Raphaël Porcher, Xavier Mariette, Olivier Hermine, Xavier Mariette, Philippe Ravaud, Serge Bureau, Maxime Dougados, Matthieu Resche‐Rigon, Pierre‐Louis Tharaux, Annick Tibi, Olivier Hermine, Élie Azoulay, Serge Bureau, Jacques Cadranel, Maxime Dougados, Joseph Emmerich, Muriel Fartoukh, Bertrand Guidet, Marc Humbert, Karine Lacombe, Matthieu Mahévas, Xavier Mariette, Frédéric Pène, Raphaël Porcher, Valérie Pourchet-Martinez, Philippe Ravaud, Matthieu Resche‐Rigon, F. Schlemmer, Pierre‐Louis Tharaux, Annick Tibi, Yazdan Yazdanpanah, Philippe Ravaud, Raphaël Porcher, Gabriel Baron, Élodie Perrodeau, Serge Bureau, Damien Vanhoye, Cécile Kedzia, Lauren Demerville, Anne Gysembergh-Houal, Alexandre Bourgoin, Matthieu Resche‐Rigon, Nabil Raked, Lakhdar Mameri, Claire Montlahuc, Lucie Biard, St.phanie Alary, Samir Hamiria, Thinhinane Bariz, Hala Semri, Dhiaa Meriem Hai, Moustafa Benafla, Mohamed Belloul, Pernelle Vauboin, Saskia Flamand, Claire Pacheco, Anouk Walter‐Petrich, E. Ya. Stan, Souad Benarab, Corine Nyanou, Maxime Dougados, Annick Tibi, Robin Charreteur, Celine Dupré, Kévin Cardet, Blandine Lehmann, Kamyl Baghli, Yazdan Yazdanpanah, Claire Madelaine, Éric D’Ortenzio, Oriane Puéchal, Caroline Semaille, Xavier Mariette, Laurent Savale, Anatole Harrois, Samy Figueiredo, Jacques Duranteau, Nadia Anguel, Arthur Pavot, Xavier Monnet, Christian Richard, Jean–Louis Teboul, Philippe Durand, Pierre Tissières, Mitja Jevnikar, Marc Humbert, David Montani, Stéphan Pavy, Gaëtane Nocturne, Samuel Bitoun, Nicolas Noël, Olivier Lambotte, L. Escaut, Stéphane Jauréguiberry, Élodie Baudry, Christiane Verny, Édouard Lefèvre, Mohamad Zaidan, Domitille Molinari, Gaël Leprun, Alain Fourreau, Laurent Cylly, Lamiae Grimaldi‐Bensouda, Myriam Virlouvet, Ramdane Meftali, Solène Fabre, Marion Licois, Asmaa Mamoune, Yacine Boudali, Clotilde Le Tiec, Céline Verstuyft, Anne-Marie Roques, Sophie Georgin‐Lavialle, Jacques Cadranel, Patricia Senet, Gilles Pialoux, A. Soria, Antoine Parrot, Helene François, N. Rozensztajn, Emmanuelle Blin, Pascaline Choinier, Juliette Camuset, Jean‐Simon Rech, A. Canellas, Camille Rolland‐Debord, Nadège Lemarié, Nicolas Belaube, Marine Nadal, Martin Siguier, Camille Petit-Hoang, Julie Chas, Élodie Drouet, Matthieu Lemoine, Audrey Phibel, Lucie Aunay, Eliane Bertrand, Sylviane Ravato, Marie Vayssettes, Anne Adda, Celine Wilpotte, Pélagie Thibaut, Julie Fillon, Isabelle Debrix, Soraya Fellahi, Jean‐Philippe Bastard, Guillaume Lefèvre, Jacques‐Eric Gottenberg, Yves Hansmann, Frédéric Blanc, Sophie Ohlmann-Caillard, Vincent Castelain, Emmanuel Chatelus, Eva Chatron, Olivier Collange, François Danion, Frédéric de Blay, Pierre Diemunsch, Sophie Diemunsch, Renaud Felten, Bernard Goichot, Valentin Greigert, Aurélien Guffroy, Bob Heger, Charlotte Kaeuffer, Loïc Kassègne, Anne‐Sophie Korganow, Pierrick Le Borgne, Nicolas Lefèbvre, Paul‐Michel Mertès, Éric Noll, M. Oberlin, Vincent Poindron, Julien Pottecher, Yvon Ruch, François Weill, Nicolás Meyer, Emmanuel Andrès, Eric Demonsant, Hakim Tayebi, G. Nisand, Stéphane Brin, Cédric Sublon, Guillaume Becker, Anne Hutt, Tristan Martin, Sophie Bayer, Catherine Metzger, A. Mékinian, Karine Lacombe, Bertrand Guidet, Noémie Abisror, Amir Adedjouma, Diane Bollens, Marion Bonneton, Nathalie Bourcicaux, Anne Bourrier, Maria Chauchard Thibault Chiarabiani, Doroth.e Chopin, Jonathan B. Cohen, Inès Devred, Bruno Donadille, Olivier Fain, Geoffrey Hariri, Vincent Jachiet, Patrick Ingliz, Marc Garnier, M. Gatfossé, E. Ghrenassia, Delphine Gobert, Bertrand Guidet, Jessica Krause Le Garrec, Cécilia Landman, Jean Remy Lavillegrand, Bénédicte Lefebvre, T. Mahévas, Sandie Mazerand, Jean Luc Meynard, Marjolaine Morgand, Zineb Ouaz.ne, Jérôme Pacanowski, S.bastien Riviere, Philippe Seksik, Harry Sokol, Heithem Soliman, Nadia Valin, Thomas Urbina, Chloé McAvoy, Maria Pereira Miranda, Gladys Aratus, Laurence Bérard, Tabassome Simon, Anne Daguenel Nguyen, E.M. Girault, Cl.mentine Mayala-Kanda, Marie Antignac, Céline Leplay, Gladys Aratus, Laurence Bérard, Tabassome Simon, Jean‐Benoît Arlet, Jean‐Luc Diehl, Florence Bellenfant, Anne Blanchard, Alexandre Buffet, Bernard Cholley, Antoine Fayol, Edouard Flamarion, Anne Godiér, Thomas Gorget, Sophie-Rym Hamada, Caroline Hauw‐Berlemont, Jean‐Sébastien Hulot, David Lebeaux, Marine Livrozet, Adrien Michon, Arthur Neuschwander, Marie-Aude Pennet, Benjamin Planquette, Brigitte Ranque, Olivier Sanchez, Geoffroy Volle, Sandrine Briois, Mathias Cornic, Virginie Elisee, Jesuthasan Denis, Juliette Djadi‐Prat, Pauline Jouany, Ramon Junquera, Mickael Henriques, Amina Kebir, Isabelle Lehir, Jeanne Meunier, Florence Patin, Val.rie Paquet, Anne Tréhan, Véronique Vigna, Brigitte Sabatier, Damien Bergerot, Charlène Jouve, Camille Knosp, Olivia Lenoir, Nassim Mahtal, Léa Resmini, X. Lescure, Jade Ghosn, Antoine Bachelard, A. Rachline, Valentina Isernia, Bao-chau, Phung, D. Vallois, Aurélie Sautereau, Catherine Neukrich, Antoine Dossier, Raphaël Borie, Bruno Crestani, Grégory Ducrocq, Philippe Gabríel Steg, Philippe Dieudé, T. Papo, Estelle Marcault, Marhaba Chaudhry, Charlène Da Silveira, Annabelle Metois, Ismahan Mahenni, Meriam Meziani, Cyndie Nilusmas, Sylvie Le Gac, Awa Ndiaye, Fran.oise Louni, M Chansombat, Zélie Julia, Solaya Chalal, Lynda Chalal, Laura D. Kramer, Jeniffer Le Grand, Ouifiya Kafif, Valentine Piquard, Sarah Tubiana, Yann Nguyen, Vasco Honsel, Emmanuel Weiss, Anaïs Codorniu, Virginie Zarrouk, Victoire de Lastours, Matthieu Uzzan, Naura Gamany, Agathe Claveirole, Alexandre Navid, Tiffanie Fouque, Yonathan Cohen, Maya Lupo, Constance Gilles, Roza Rahli, Zeina Louis, David Boutboul, Lionel Galicier, Élie Azoulay, Lionel Galicier, Yaël Amara, Gabrielle Archer, Élie Azoulay, Amira Benattia, Anne Bergeron, Louise Bondeelle, Nathalie De Castro, Melissa Clément, Michaël Darmon, Blandine Denis, Clairelyne Dupin, E. Feredj, Delphine Feyeux, Adrien Joseph, Etienne Lenglin, Pierre Le Guen, Geoffroy Liégeon, Gwenaël Lorillon, Asma Mabrouki, Éric Mariotte, G. Martin de Frémont, Adrien Mirouse, Jean‐Michel Molina, Régis Peffault de Latour, Éric Oksenhendler, Julien Saussereau, Abdellatif Tazi, Jean‐Jacques Tudesq, Lara Zafrani, Isabelle Brindele, Emmanuelle Bugnet, Karine Celli Lebras, Julien Chabert, Lamia Djaghout, Catherine Fauvaux, Anne Lise Jegu, Ewa Kozakiewicz, Martine Meunier, Marie-Thérèse Tremorin, Claire Davoine, Isabelle Madelaine, Sophie Caillat‐Zucman, Constance Delaugerre, Florence Morin, D. Sène, Ruxandra Burlacu, Benjamin G. Chousterman, Bruno Mégarbanne, Pascal Richette, Jean‐Pierre Riveline, Aline Frazier, Éric Vicaut, Laure Berton, Tassadit Hadjam, Miguel Alejandro Vazquez-Ibarra, Clément Jourdaine, Olivia Tran, V. Jouis, Aude Jacob, Julie Smati, Stéphane Renaud, Claire Pernin, Lydia Suarez, Luca Semerano, S. Abad, Ruben B. nainous, Nicolas Bonnet, Céline Comparon, Yves Cohen, Hugues Cordel, Robin Dhôte, Nathalie Dournon, Boris Duchemann, Nathan Ebstein, Thomas Gille, B. Giroux-Leprieur, Jeanne Goupil de Bouillé, Hilario Nunès, Johanna Oziel, Dominique Roulot, Lucile Sésé, ClaireTantet, Y. Uzunhan, Coralie Bloch‐Queyrat, Vincent Lévy, Fadhila Messani, Mohammed Rahaoui, Mylène Petit, Sabrina Brahmi, Vanessa Rathoin, Marthe Rigal, Nathalie Costedoat-Chalumeau, Liem Binh Luong, Frédéric Pène, Zakaria Ait Hamou, Sarah Benghanem, P. Blanche, Nicolas Carlier, Benjamin Chaigne, R. Gauzit, Hassan Joumaa, Mathieu Jozwiak, Marie Lachétre, Hélène Lafoeste, Odie Launay, Paul Legendre, Jonathan Marey, Caroline Morbieu, Lola‐Jade Palmieri, Tali‐Anne Szwebel, Hendy Abdoul, Alexandra Bruneau, Audrey Beclin-Clabaux, Charly Larrieu, Pierre Montanari, Éric Dufour, Ada Clarke, Catherine Le Bourlout, Nathalie Marin, Nathalie Menage, Samira Saleh-Mghir, Mamadou Salif Cisse, Kahina Cheref, Corinne Guérin, Jérémie Zerbit, Marc Michel, Sébastien Gallien, Étienne Crickx, Benjamin Le Vavasseur, Emmanuelle Kempf, Karim Jaffal, William Vindrios, Julie Oniszczuk, Marc Michel, Matthieu Mahévas, Constance Guillaud, F. Schlemmer, Pascal Lim, Eléna Foïs, Giovanna Melica, Marie Matignon, Maud Jalabert, Jean‐Daniel Lelièvre, David Schmitz, Marion Bourhis, Sylia Belazouz, Laetitia Languille, Caroline Boucle, Nelly Cita, Agnés Didier, Fahem Froura, Katia Ledudal, Thiziri Sadaoui, Alaki Thiemele, Delphine Le Febvre De Bailly, Muriel Carvhalo Verlinde, Julien Mayaux, P. Cacoub, David Saadoun, Mathieu Vautier, Hélène Bugaut, Olivier Benvéniste, Yves Allenbach, Gaëlle Leroux, Aude Rigolet, Perrine Guillaume-Jugnot, F. Domont, A.C. Desbois, C. Comarmond, N. Champtiaux, S. Toquet, Amine Ghembaza, Matheus Vieira, Georgina Maalouf, Gonçalo Boleto, Yasmina Ferfar, Jean‐Christophe Corvol, C.line Louapre, Sara Sambin, Louise‐Laure Mariani, Carine Karachi, Florence Tubach, Candice Estellat, Linda Gimeno, Karine Martin, Aïcha Bah, Vixra Keo, Sabrine Ouamri, Yasmine Messaoudi, Nessima Yelles, Pierre Faye, Sébastien Cavelot, Cecile Larcheveque, Laurence Annonay, Jaouad Benhida, Aida Zahrate-Ghoul, Soumeya Hammal, Ridha Belilita, Fanny Charbonnier, Claire Aguilar, Fanny Alby‐Laurent, Carole Burger, Clara Campos-Vega, Nathalie Chavarot, Benjamin Fournier, Claire Rouzaud, Damien Vimpère, Caroline Elie, Prissile Bakouboula, Laure Choupeaux, Sophie Granville, Elodie Issorat, Christine Broissand, Marie‐Alexandra Alyanakian, Guillaume Géri, Nawal Derridj, Naima Sguiouar, Hakim Meddah, Mourad Djadel, Hélène Chambrin-Lauvray, Jean‐Charles Duclos‐Vallée, Faouzi Saliba, Sophie‐Caroline Sacleux, Ilias Kounis, Sonia Tamazirt, E. Rudant, Jean‐Marie Michot, Annabelle Stoclin, Émeline Colomba, Fanny Pommeret, Christophe Willekens, Rosa da Silva, Valérie Dejean, Yasmina Mekid, Ines Ben-Mabrouk, Florence Netzer, Caroline Pradon, Laurence Drouard, Valérie Camara‐Clayette, Alexandre Morel, Gilles Garcia, Abolfazl Mohebbi, Férial Berbour, Mélanie Dehais, Anne-Lise Pouliquen, Alison Klasen, Loren Soyez-Herkert, Jonathan London, Jonathan London, Younes Keroumi, Emmanuelle Guillot, Guillaume Grailles, Younes El Amine, Fanny Defrancq, Hanane Fodil, Chaouki Bouras, Dominique Dautel, Nicolas Gambier, Thierno Dieye, Boris Bienvenu, Victor Lançon, Laurence Lecomte, Kristina Beziriganyan, Belkacem Asselate, Laure Allanic, Eléna Kiouris, Marie-Hélène Legros, Christine Lemagner, Pascal Martel, Vincent Provitolo, Félix Ackermann, Mathilde Marchand, Aurélie Chan Hew Wai, Dimitri Frémont, Elisabeth Coupez, Mireille Adda, Frédéric Duee, Lise Bernard, Antoine Gros, Estelle Henry, Claire Courtin, Anne Pattyn, Pierre‐Grégoire Guinot, Marc Bardou, Agnès Maurer, Julie Jambon, Amélie Cransac, C Pernot, Bruno Mourvillier, Eric Marquis, P Benoit, Damien Roux, Coralie Gernez, Cécile Yelnik, Julien Poissy, Mandy Nizard, Fanette Deniès, Hélène Gros, Jean‐Jacques Mourad, Emmanuelle Sacco, Sophie Renet, Florence Ader, Yazdan Yazdanpanah, France Mentré, Nathan Peiffer-Smadja, F.X. Lescure, Julien Poissy, Lila Bouadma, Jean‐François Timsit, Bruno Lina, Florence Morfin‐Sherpa, Maude Bouscambert, Alexandre Gaymard, Gilles Peytavin, Laurent Abel, Jérémie Guedj, Claire Andréjak, Charles Burdet, Cédric Laouenan, Drifa Belhadi, Axelle Dupont, Toni Alfaiate, Basma Basli, Anissa Chair, Sai͏̈d Laribi, Julie Level, M Schneider, Marie-Capucine Tellier, Aline Dechanet, Dominique Costagliola, Benjamin Terrier, Mickaël Ohana, S. Couffin-Cadiergues, Hélène Espérou, Clément Delmas, Juliette Saillard, Claire Fougerou, Laëtitia Moinot, Linda Wittkop, Carole Cagnot, Soizic Le Mestre, D. Lebrasseur-Longuet, Ventzislava Petrov–Sanchez, Alpha Diallo, Noémie Mercier, V. Icard, Benjamin Leveau, Sarah Tubiana, B. Hamzé, A Gelley, Marion Noret, Éric D’Ortenzio, Oriane Puéchal, Caroline Semaille, Tobias Welte, José Artur Paiva, Monika Halánová, Marie Paule Kiény, E. Balssa, Carmen Birkle, S. Gibowski, Elaine Landry, A. Le Goff, Laurence Moachon, C. Moins, L. Wadouachi, Christelle Paul, Axel Levier, David Bougon, Félix Djossou, Loïc Epelboin, J. Dellamonica, Charles‐Hugo Marquette, Caroline Robert, Sébastien Gibot, É. Senneville, Vanessa Jean-Michel, Yoann Zerbib, C Chirouze, Alexandre Boyer, Charles Cazanave, Didier Gruson, Denis Malvy, P. Andreu, Jean‐Pierre Quenot, Nicolas Terzi, Karine Faure, Cyrille Chabartier, Vincent Le Moing, Kada Klouche, Tristan Ferry, F, Valour, Benjamin Gaborit, Emmanuel Canet, Paul Le Turnier, David Boutoille, Firouzé Bani‐Sadr, François Bénézit, Matthieu Revest, Charlotte Cameli, Antonia Caro, MJ Ngo Um Tegue, Yves Le Tulzo, Bruno Laviolle, Fabrice Laine, Guillaume Thiéry, Ferhat Meziani, Yves Hansmann, Walid Oulehri, Charles Tacquard, Fanny Vardon‐Bounes, Béatrice Riu-Poulenc, M. Murris‐Espin, Lise Bernard, Denis Garot, O. Hinschberger, M. Martinot, Cédric Bruel, B. Pilmis, Olivier Bouchaud, Paul Loubet, Claire Roger, Xavier Monnet, Samy Figueiredo, Virginie Godard, Jean‐Paul Mira, Marie Lachâtre, Solen Kernéis, Jérôme Aboab, N. Sayre, Flora Crockett, David Lebeaux, Alexandre Buffet, Jean‐Luc Diehl, Antoine Fayol, Jean‐Sébastien Hulot, Marine Livrozet, Armand Mekontso Dessap, C. Ficko, F. Stefan, Jérôme Le Pavec, Julien Mayaux, Hafid Ait‐Oufella, Jean‐Michel Molina, Gilles Pialoux, Muriel Fartoukh, Julien Textoris, Myriam Brossard, Asma Essat, Emmanuelle Netzer, Yoann Riault, Marc Ghislain, Lydie Béniguel, Michaël Génin, L. Gouichiche, Laëtitia Moinot, Christine Bétard, Linda Wittkop, Leïla Belkhir, Antoine Altdorfer, V Fraipont Centro, Sandra Bráz, JM Ferreira Ribeiro, José Artur Paiva, R Roncon Alburqueque, Marc J. Berna, M. Alexandre, Bernd Lamprecht, A. Egle, Richard Greil, Richard Greil, Michael Joannidis, Thomas F. Patterson, Philip O. Ponce, Barbara S. Taylor, Jan E. Patterson, Jason E. Bowling, Heta Javeri, André C. Kalil, LuAnn Larson, Angela Hewlett, Aneesh K. Mehta, Nadine Rouphael, Youssef Saklawi, Nicholas Scanlon, Jessica Traenkner, Ronald P. Trible, Emmanuel B. Walter, Noel Ivey, Thomas L Holland, Guillermo M. Ruiz‐Palacios, Alfredo Ponce‐de‐León, Sandra Rajme‐López, Lanny Hsieh, Alpesh Amin, Miki Watanabe, Helen S. Lee, Susan Kline, Joanne Billings, Brooke Noren, Hyun Kim, Tyler D. Bold, Victor F. Tapson, Jonathan Grein, Fayyaz S. Sutterwala, Nicole M. Iovine, Lars K. Beattie, Rebecca Wakeman, Matthew Shaw, Mamta K. Jain, Satish Mocherla, Jessica Meisner, Amneris E. Luque, Daniel A. Sweeney, Constance A. Benson, Farhana Ali, Robert L. Atmar, Hana M. El Sahly, Jennifer A. Whitaker, Ann R. Falsey, Angela R Branche, Cheryl Rozario, Justino Regalado Pineda, José Arturo Martínez-Orozco, David Chien Lye, Sean Wei Xiang Ong, Po Ying Chia, Barnaby Edward Young, Uriel Sandkovsky, Mezgebe Berhe, Clinton Haley, Emma Dishner, Valeria D Cantos, Colleen F. Kelley, Paulina A. Rebolledo Esteinou, Sheetal Kandiah, Sarah B. Doernberg, Pierre-Cedric B. Crouch, Hannah Jang, Anne F. Luetkemeyer, Jay Dwyer, Stuart H. Cohen, George R. Thompson, Hien Nguyen, Robert W. Finberg, Jennifer Wang, Juan Perez-Velazquez, Mireya Wessolossky, Patrick Jackson, Taison D. Bell, M. West, Babafemi Taiwo, Karen Krueger, Johnny Perez, Triniece Pearson, Catharine I. Paules, Kathleen G. Julian, Danish Ahmad, Alexander Hajduczok, Henry Arguinchona, Christa Arguinchona, Nathaniel Erdmann, Paul Goepfert, Neera Ahuja, Maria G. Frank, David Wyles, Heather Young, Myoung‐don Oh, Wan Beom Park, Chang Kyung Kang, Vincent C. Marconi, Abeer Moanna, Sushma K. Cribbs, Telisha Harrison, Eu Suk Kim, Jongtak Jung, Kyoung‐Ho Song, Hong Bin Kim, Seow Yen Tan, Humaira Shafi, Jaime Chien, Raymond KC. Fong, Daniel D. Murray, Jens Lundgren, Henrik Nielsen, Tomas Ø. Jensen, Barry S. Zingman, Robert Grossberg, Paul Riska, Otto O. Yang, Jenny Ahn, Rubi Arias, Rekha R. Rapaka, Naomi Hauser, James D. Campbell, William R. Short, Pablo Tebas, Jillian T. Baron, Susan McLellan, Lucas S. Blanton, Justin B Seashore, C. Buddy Creech, Todd W. Rice, Shannon L. Walker, Isaac Thomsen, Diego López de Castilla, Jason W. Van Winkle, Francis X. Riedo, Surinder Pada, Alvin DY. Wang, Li‐Fong Lin, Michelle Harkins, Grégory Mertz, Néstor Sosa, Louis Yi Ann Chai, Paul Anantharajah Tambyah, Sai Meng Tham, Sophia Archuleta, Gabriel Yan, David A Lindholm, Ana E Markelz, Katrin Mende, Richard A. Mularski, Elizabeth Hohmann, Mariam Torres-Soto, Nikolaus Jilg, Ryan C. Maves, Gregory Utz, Sarah L. George, Daniel F. Hoft, James D. Brien, Roger Paredes, Lourdes Mateu, Cora Loste, Princy Kumar, Sarah Thornton, Sharmila Mohanraj, Noreen A. Hynes, Lauren Sauer, Christopher Colombo, Christina Schofield, Rhonda E Colombo, Susan E. Chambers, Richard Novák, Andrea Wendrow, Samir K. Gupta, Tida Lee, Tahaniyat Lalani, Mark Holodniy, Aarthi Chary, Nikhil Huprikar, Anuradha Ganesan, Norio Ohmagari, Ayako Mikami, David Price, C.J. Duncan, Kerry Dierberg, Henry J. Neumann, Stephanie N. Taylor, Alisha Lacour, Najy Masri, Edwin Swiatlo, Kyle Widmer, James D. Neaton, Mary Bessesen, David S. Stephens, Timothy Burgess, Timothy M. Uyeki, Robert Walker, G. Lynn Marks, Anu Osinusi, Huyen Cao, Anabela Cardoso, Stephanie de Bono, Douglas Schlichting, Kevin K. Chung, Jennifer L. Ferreira, Michelle Green, Mat Makowski, Michael R. Wierzbicki, Tom Conrad, Jill El-Khorazaty, Heather Hill, Tyler Bonnett, Nikki Gettinger, Theresa Engel, Teri Lewis, Jing Wang, John H. Beigel, Kay M. Tomashek, Varduhi Ghazaryan, Tatiana Beresnev, Seema Nayak, Lori E. Dodd, Walla Dempsey, Effie Nomicos, Marina Lee, Rhonda Pikaart-Tautges, Mohammed Elsafy, Robert Jurao, Hyung Il Koo, Michael A. Proschan, Tammy Yokum, Janice Arega, Ruth H. Florese, Jocelyn Voell, Richard T. Davey, André C. Kalil, LuAnn Larson, Angela Hewlett, Thomas F. Patterson, Philip O. Ponce, Jan E. Patterson, Barbara S. Taylor, Jason E. Bowling, Ruth C. Serrano, Aneesh K. Mehta, Jessica Traenkner, Nadine Rouphael, Zanthia Wiley, Varun K. Phadke, Nathaniel Erdmann, Paul Goepfert, Carlos A. Gómez, Theresa A. Sofarelli, Laura Certain, Hannah N. Imlay, Cameron R. Wolfe, Emily R. Ko, John J. Engemann, Emmanuel B. Walter, Mamta K. Jain, Satish Mocherla, Jessica Meisner, Guillermo M. Ruiz‐Palacios, Alfredo Ponce‐de‐León, Sandra Rajme‐López, Susan Kline, Joanne Billings, Hyun Kim, Justino Regalado Pineda, José Arturo Martínez-Orozco, Nora Bautista Felix, Claire Ramsay Wan, Sammy T. Elmor, Laurel Bristow, Michelle Harkins, Grégory Mertz, Néstor Sosa, Patrick Jackson, Taison D. Bell, M. West, Nicole M. Iovine, Marie‐Carmelle Elie, Victor F. Tapson, Jonathan Grein, Fayyaz S. Sutterwala, Myoung‐don Oh, Pyoeng Gyun Choe, Chang Kyung Kang, Richard A. Mularski, Catharine I. Paules, Kevin S. Rhie, Rezhan H. Hussein, Dilek İnce, Patricia Winokur, Jin Takasaki, Ayako Mikami, Sho Saito, Daniel A. Sweeney, Constance A. Benson, Kimberly McConnell, Uriel Sandkovsky, Mezgebe Berhe, Emma Dishner, David Wyles, Maria G. Frank, Ellen Sarcone, Mamta K. Jain, Satish Mocherla, Jessica Meisner, Sarah B. Doernberg, Pierre-Cedric B. Crouch, Hannah Jang, Elizabeth Hohmann, Nikolaus Jilg, Kevin A. Grimes, Katherine K. Perez, Charles Janak, Hana M. El Sahly, Jennifer A. Whitaker, Valeria D Cantos, Paulina A. Rebolledo, John Gharbin, Robert Grossberg, Barry S. Zingman, Paul Riska, Allison Lambert, Henry Arguinchona, Christa Arguinchona, Diego López de Castilla, Jason W. Van Winkle, Diego F. Zea, Eu Suk Kim, Jongtak Jung, Kyoung‐Ho Song, Hong Bin Kim, Anne F. Luetkemeyer, Jay Dwyer, Emma Bainbridge, David C. Hostler, Jordanna Hostler, Brian T. Shahan, Lanny Hsieh, Alpesh Amin, Miki Watanabe, William R. Short, Pablo Tebas, Jillian T. Baron, Neera Ahuja, Evelyn Ling, Minjoung Go, Otto O. Yang, Jenny Ahn, Rubi Arias, Rekha R. Rapaka, Fleesie Hubbard, James D. Campbell, Stuart H. Cohen, Melony Chakrabarty, Maryrose Laguio‐Vila, Edward E. Walsh, Ann R. Falsey, Stephanie N. Taylor, Najy Masri, Alisha Lacour, Tida Lee, Tahaniyat Lalani, Hana M. El Sahly, Jennifer A. Whitaker, David A Lindholm, Ana E Markelz, Katrin Mende, Angela R Branche, Christopher Colombo, Christina Schofield, Rhonda E Colombo, Faheem W. Guirgis, Mark Holodniy, Aarthi Chary, Mary Bessesen, Noreen A. Hynes, Lauren Sauer, Vincent C. Marconi, Abeer Moanna, Telisha Harrison, David Chien Lye, Sean Wei Xiang Ong, Po Ying Chia, Nikhil Huprikar, Anuradha Ganesan, Christian Madar, Richard Novák, Andrea Wendrow, Scott Borgetti, Sarah L. George, Daniel F. Hoft, James D. Brien, Susan McLellan, Corri B. Levine, Joy Nock, Seow Yen Tan, Humaira Shafi, Jaime Chien, Keith Candiotti, Robert W. Finberg, Jennifer Wang, Mireya Wessolossky, Ryan C. Maves, Gregory Utz, Susan E. Chambers, Timothy Burgess, Julia S Rozman, Fernando Dangond, Yann Hyvert, Andrea Seitzinger, Anu Osinusi, Huyen Cao, Kevin K. Chung, Jennifer L. Ferreira, Michelle Green, Mat Makowski, Tom Conrad, Kaitlyn Cross, Jill El-Khorazaty, Heather Hill, Stephanie Pettibone, Michael R. Wierzbicki, Tyler Bonnett, Nikki Gettinger, Theresa Engel, Teri Lewis, Jing Wang, John H. Beigel, Kay M. Tomashek, Varduhi Ghazaryan, Tatiana Beresnev, Seema Nayak, Lori E. Dodd, Walla Dempsey, Gregory A. Deye, Effie Nomicos, Rhonda Pikaart-Tautges, Mohammed Elsafy, Robert Jurao, Hyung Il Koo, Michael A. Proschan, Richard T. Davey, Tammy Yokum, Janice Arega, Ruth H. Florese · 发表于：EClinicalMedicine · 年份：2024 · DOI：10.1016/j.eclinm.2024.102472 · 被引用次数：8 · 研究领域：Pediatric health and respiratory diseases、Herbal Medicine Research Studies、Diverse Scientific Research Studies

Background: Although immunomodulators have established benefit against the new coronavirus disease (COVID-19) in general, it is uncertain whether such agents improve outcomes without increasing the risk of secondary infections in the specific subgroup of previously immunocompromised patients. We assessed the effect of immunomodulators on outcomes of immunocompromised patients hospitalized for COVID-19. Methods: The protocol was prospectively registered with PROSPERO (CRD42022335397). MEDLINE, Cochrane Central Register of Controlled Trials and references of relevant articles were searched up to 01-06-2022. Authors of potentially eligible randomized controlled trials were contacted to provide data on immunocompromised patients randomized to immunomodulators vs control (i.e., placebo or standard-of-care). Findings: Eleven randomized controlled trials involving 397 immunocompromised patients hospitalized for COVID-19 were included. Ten trials had low risk of bias. There was no difference between immunocompromised patients randomized to immunomodulators vs control regarding mortality [30/182 (16.5%) vs 41/215 (19.1%); RR 0.93, 95% CI 0.61-1.41; p = 0.74], secondary infections (RR 1.00, 95% CI 0.64-1.58; p = 0.99) and change in World Health Organization ordinal scale from baseline to day 15 (weighed mean difference 0.27, 95% CI -0.09-0.63; p = 0.15). In subgroup analyses including only patients with hematologic malignancy, only trials with low risk of bias, only trials administerin...