Filling in the Gaps: Updates on Doxycycline Prophylaxis for Bacterial Sexually Transmitted Infections

作者：Aniruddha Hazra, Moira McNulty, Maria Pyra, Jade Pagkas-Bather, José I. Gutierrez, Jim Pickett, Jenell Stewart, Robert Bolan, Jean‐Michel Molina, Connie Celum, Anne F. Luetkemeyer, Jeffrey D. Klausner · 发表于：Clinical Infectious Diseases · 年份：2024 · DOI：10.1093/cid/ciae062 · 被引用次数：38 · 研究领域：Reproductive tract infections research、Syphilis Diagnosis and Treatment、HIV/AIDS Research and Interventions

Over the past two decades, cases of sexually transmitted infections (STIs) due to syphilis, gonorrhea, and chlamydia have been rising in the United States, disproportionately among gay, bisexual, and other men who have sex with men (MSM), as well as racial and ethnic minorities of all genders. In this review, we address updates about the evidence on doxycycline post-exposure prophylaxis (doxy-PEP) for prevention of bacterial STIs, including efficacy, safety, antimicrobial resistance (AMR), acceptability, modeling population impact, and evolving guidelines for use. Equitable implementation of doxy-PEP will require evaluation of who is offered and initiates it, understanding patterns of use and longer-term STI incidence and AMR, provider training, and tailored community education.