Base-Promoted Ring-Opening Hydroxylation of Cyclic Sulfonium Salts

作者：Ziyu Wang, Zeyu Shao, Cheng Wang, Jian Wen · 发表于：The Journal of Organic Chemistry · 年份：2024 · DOI：10.1021/acs.joc.3c02546 · 被引用次数：29 · 研究领域：Sulfur-Based Synthesis Techniques、Catalytic C–H Functionalization Methods、Synthesis and Catalytic Reactions

Herein, we reported a general strategy for the synthesis of sulfur-containing primary alcohol derivatives by base-promoted ring-opening hydroxylation of cyclic sulfonium salts. A variety of sulfonium salts were successfully transformed into the desired hydroxylated products in moderate to excellent yields with good functional group tolerance. Moreover, the one-pot synthesis, scale-up reaction, and late-stage functionalization of complex molecules demonstrated the practicability of this synthetic protocol in the field of synthetic chemistry.